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Protective Effects of Polyphenol-Rich Extracts against Neurotoxicity Elicited by Paraquat or Rotenone in Cellular Models of Parkinson's Disease.
Tambe MA, de Rus Jacquet A, Strathearn KE, Hensel JA, Colón BD, Chandran A, Yousef GG, Grace MH, Ferruzzi MG, Wu Q, Simon JE, Lila MA, Rochet JC. Tambe MA, et al. Among authors: strathearn ke. Antioxidants (Basel). 2023 Jul 20;12(7):1463. doi: 10.3390/antiox12071463. Antioxidants (Basel). 2023. PMID: 37508001 Free PMC article.
Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models.
Cooper AA, Gitler AD, Cashikar A, Haynes CM, Hill KJ, Bhullar B, Liu K, Xu K, Strathearn KE, Liu F, Cao S, Caldwell KA, Caldwell GA, Marsischky G, Kolodner RD, Labaer J, Rochet JC, Bonini NM, Lindquist S. Cooper AA, et al. Among authors: strathearn ke. Science. 2006 Jul 21;313(5785):324-8. doi: 10.1126/science.1129462. Epub 2006 Jun 22. Science. 2006. PMID: 16794039 Free PMC article.
The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis.
Gitler AD, Bevis BJ, Shorter J, Strathearn KE, Hamamichi S, Su LJ, Caldwell KA, Caldwell GA, Rochet JC, McCaffery JM, Barlowe C, Lindquist S. Gitler AD, et al. Among authors: strathearn ke. Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):145-50. doi: 10.1073/pnas.0710685105. Epub 2007 Dec 27. Proc Natl Acad Sci U S A. 2008. PMID: 18162536 Free PMC article.
Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models.
Su LJ, Auluck PK, Outeiro TF, Yeger-Lotem E, Kritzer JA, Tardiff DF, Strathearn KE, Liu F, Cao S, Hamamichi S, Hill KJ, Caldwell KA, Bell GW, Fraenkel E, Cooper AA, Caldwell GA, McCaffery JM, Rochet JC, Lindquist S. Su LJ, et al. Among authors: strathearn ke. Dis Model Mech. 2010 Mar-Apr;3(3-4):194-208. doi: 10.1242/dmm.004267. Epub 2009 Dec 28. Dis Model Mech. 2010. PMID: 20038714 Free PMC article.
12 results