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Human fertilization in vivo and in vitro requires the CatSper channel to initiate sperm hyperactivation.
Young S, Schiffer C, Wagner A, Patz J, Potapenko A, Herrmann L, Nordhoff V, Pock T, Krallmann C, Stallmeyer B, Röpke A, Kierzek M, Biagioni C, Wang T, Haalck L, Deuster D, Hansen JN, Wachten D, Risse B, Behre HM, Schlatt S, Kliesch S, Tüttelmann F, Brenker C, Strünker T. Young S, et al. Among authors: strunker t. J Clin Invest. 2024 Jan 2;134(1):e173564. doi: 10.1172/JCI173564. J Clin Invest. 2024. PMID: 38165034 Free PMC article.
Action of steroids and plant triterpenoids on CatSper Ca2+ channels in human sperm.
Brenker C, Schiffer C, Wagner IV, Tüttelmann F, Röpke A, Rennhack A, Kaupp UB, Strünker T. Brenker C, et al. Among authors: strunker t. Proc Natl Acad Sci U S A. 2018 Jan 16;115(3):E344-E346. doi: 10.1073/pnas.1717929115. Epub 2018 Jan 5. Proc Natl Acad Sci U S A. 2018. PMID: 29305558 Free PMC article. No abstract available.
CRISP2 Is a Regulator of Multiple Aspects of Sperm Function and Male Fertility.
Lim S, Kierzek M, O'Connor AE, Brenker C, Merriner DJ, Okuda H, Volpert M, Gaikwad A, Bianco D, Potter D, Prabhakar R, Strünker T, O'Bryan MK. Lim S, et al. Among authors: strunker t. Endocrinology. 2019 Apr 1;160(4):915-924. doi: 10.1210/en.2018-01076. Endocrinology. 2019. PMID: 30759213
Rotational motion and rheotaxis of human sperm do not require functional CatSper channels and transmembrane Ca2+ signaling.
Schiffer C, Rieger S, Brenker C, Young S, Hamzeh H, Wachten D, Tüttelmann F, Röpke A, Kaupp UB, Wang T, Wagner A, Krallmann C, Kliesch S, Fallnich C, Strünker T. Schiffer C, et al. Among authors: strunker t. EMBO J. 2020 Feb 17;39(4):e102363. doi: 10.15252/embj.2019102363. Epub 2020 Jan 19. EMBO J. 2020. PMID: 31957048 Free PMC article.
The antidepressant Sertraline inhibits CatSper Ca2+ channels in human sperm.
Rahban R, Rehfeld A, Schiffer C, Brenker C, Egeberg Palme DL, Wang T, Lorenz J, Almstrup K, Skakkebaek NE, Strünker T, Nef S. Rahban R, et al. Among authors: strunker t. Hum Reprod. 2021 Sep 18;36(10):2638-2648. doi: 10.1093/humrep/deab190. Hum Reprod. 2021. PMID: 34486673 Free PMC article.
46 results