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Targeting receptor complexes: a new dimension in drug discovery.
Rosenbaum MI, Clemmensen LS, Bredt DS, Bettler B, Strømgaard K. Rosenbaum MI, et al. Among authors: stromgaard k. Nat Rev Drug Discov. 2020 Dec;19(12):884-901. doi: 10.1038/s41573-020-0086-4. Epub 2020 Nov 11. Nat Rev Drug Discov. 2020. PMID: 33177699 Review.
Targeting the γ-Aminobutyric Acid Type B (GABAB) Receptor Complex: Development of Inhibitors Targeting the K+ Channel Tetramerization Domain (KCTD) Containing Proteins/GABAB Receptor Protein-Protein Interaction.
Sereikaite V, Fritzius T, Kasaragod VB, Bader N, Maric HM, Schindelin H, Bettler B, Strømgaard K. Sereikaite V, et al. Among authors: stromgaard k. J Med Chem. 2019 Oct 10;62(19):8819-8830. doi: 10.1021/acs.jmedchem.9b01087. Epub 2019 Sep 25. J Med Chem. 2019. PMID: 31509708
Heterotrimeric G Proteins as Therapeutic Targets in Drug Discovery.
Li J, Ge Y, Huang JX, Strømgaard K, Zhang X, Xiong XF. Li J, et al. Among authors: stromgaard k. J Med Chem. 2020 May 28;63(10):5013-5030. doi: 10.1021/acs.jmedchem.9b01452. Epub 2019 Dec 26. J Med Chem. 2020. PMID: 31841625 Review.
Site-Specific Phosphorylation of PDZ Domains.
Ma S, Strømgaard K, Clemmensen LS. Ma S, et al. Among authors: stromgaard k. Methods Mol Biol. 2020;2133:235-261. doi: 10.1007/978-1-0716-0434-2_12. Methods Mol Biol. 2020. PMID: 32144671
PDZ Domains as Drug Targets.
Christensen NR, Čalyševa J, Fernandes EFA, Lüchow S, Clemmensen LS, Haugaard-Kedström LM, Strømgaard K. Christensen NR, et al. Among authors: stromgaard k. Adv Ther (Weinh). 2019 Jul;2(7):1800143. doi: 10.1002/adtp.201800143. Epub 2019 Apr 24. Adv Ther (Weinh). 2019. PMID: 32313833 Free PMC article. Review.
Targeting the APP-Mint2 Protein-Protein Interaction with a Peptide-Based Inhibitor Reduces Amyloid-β Formation.
Bartling CRO, Jensen TMT, Henry SM, Colliander AL, Sereikaite V, Wenzler M, Jain P, Maric HM, Harpsøe K, Pedersen SW, Clemmensen LS, Haugaard-Kedström LM, Gloriam DE, Ho A, Strømgaard K. Bartling CRO, et al. Among authors: stromgaard k. J Am Chem Soc. 2021 Jan 20;143(2):891-901. doi: 10.1021/jacs.0c10696. Epub 2021 Jan 5. J Am Chem Soc. 2021. PMID: 33398998 Free PMC article.
A High-Affinity Peptide Ligand Targeting Syntenin Inhibits Glioblastoma.
Haugaard-Kedström LM, Clemmensen LS, Sereikaite V, Jin Z, Fernandes EFA, Wind B, Abalde-Gil F, Daberger J, Vistrup-Parry M, Aguilar-Morante D, Leblanc R, Egea-Jimenez AL, Albrigtsen M, Jensen KE, Jensen TMT, Ivarsson Y, Vincentelli R, Hamerlik P, Andersen JH, Zimmermann P, Lee W, Strømgaard K. Haugaard-Kedström LM, et al. Among authors: stromgaard k. J Med Chem. 2021 Feb 11;64(3):1423-1434. doi: 10.1021/acs.jmedchem.0c00382. Epub 2021 Jan 27. J Med Chem. 2021. PMID: 33502198
Chemical Synthesis of PDZ Domains.
Kossmann C, Ma S, Clemmensen LS, Strømgaard K. Kossmann C, et al. Among authors: stromgaard k. Methods Mol Biol. 2021;2256:193-216. doi: 10.1007/978-1-0716-1166-1_12. Methods Mol Biol. 2021. PMID: 34014524
152 results