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FDA-approved selective estrogen receptor modulators inhibit Ebola virus infection.
Johansen LM, Brannan JM, Delos SE, Shoemaker CJ, Stossel A, Lear C, Hoffstrom BG, Dewald LE, Schornberg KL, Scully C, Lehár J, Hensley LE, White JM, Olinger GG. Johansen LM, et al. Among authors: stossel a. Sci Transl Med. 2013 Jun 19;5(190):190ra79. doi: 10.1126/scitranslmed.3005471. Sci Transl Med. 2013. PMID: 23785035 Free PMC article.
A screen of approved drugs and molecular probes identifies therapeutics with anti-Ebola virus activity.
Johansen LM, DeWald LE, Shoemaker CJ, Hoffstrom BG, Lear-Rooney CM, Stossel A, Nelson E, Delos SE, Simmons JA, Grenier JM, Pierce LT, Pajouhesh H, Lehár J, Hensley LE, Glass PJ, White JM, Olinger GG. Johansen LM, et al. Among authors: stossel a. Sci Transl Med. 2015 Jun 3;7(290):290ra89. doi: 10.1126/scitranslmed.aaa5597. Sci Transl Med. 2015. PMID: 26041706
Inhibition of heat-shock protein 90 reduces Ebola virus replication.
Smith DR, McCarthy S, Chrovian A, Olinger G, Stossel A, Geisbert TW, Hensley LE, Connor JH. Smith DR, et al. Among authors: stossel a. Antiviral Res. 2010 Aug;87(2):187-94. doi: 10.1016/j.antiviral.2010.04.015. Epub 2010 May 7. Antiviral Res. 2010. PMID: 20452380 Free PMC article.
Author Correction: Constrained catecholamines gain β2AR selectivity through allosteric effects on pocket dynamics.
Xu X, Shonberg J, Kaindl J, Clark MJ, Stößel A, Maul L, Mayer D, Hübner H, Hirata K, Venkatakrishnan AJ, Dror RO, Kobilka BK, Sunahara RK, Liu X, Gmeiner P. Xu X, et al. Among authors: stossel a. Nat Commun. 2023 May 24;14(1):2992. doi: 10.1038/s41467-023-38820-y. Nat Commun. 2023. PMID: 37225685 Free PMC article. No abstract available.
An allosteric modulator binds to a conformational hub in the β2 adrenergic receptor.
Liu X, Kaindl J, Korczynska M, Stößel A, Dengler D, Stanek M, Hübner H, Clark MJ, Mahoney J, Matt RA, Xu X, Hirata K, Shoichet BK, Sunahara RK, Kobilka BK, Gmeiner P. Liu X, et al. Among authors: stossel a. Nat Chem Biol. 2020 Jul;16(7):749-755. doi: 10.1038/s41589-020-0549-2. Epub 2020 Jun 1. Nat Chem Biol. 2020. PMID: 32483378 Free PMC article.
Structure-Based Design and Discovery of New M2 Receptor Agonists.
Fish I, Stößel A, Eitel K, Valant C, Albold S, Huebner H, Möller D, Clark MJ, Sunahara RK, Christopoulos A, Shoichet BK, Gmeiner P. Fish I, et al. Among authors: stossel a. J Med Chem. 2017 Nov 22;60(22):9239-9250. doi: 10.1021/acs.jmedchem.7b01113. Epub 2017 Nov 13. J Med Chem. 2017. PMID: 29094937 Free PMC article.
The experimental power of FR900359 to study Gq-regulated biological processes.
Schrage R, Schmitz AL, Gaffal E, Annala S, Kehraus S, Wenzel D, Büllesbach KM, Bald T, Inoue A, Shinjo Y, Galandrin S, Shridhar N, Hesse M, Grundmann M, Merten N, Charpentier TH, Martz M, Butcher AJ, Slodczyk T, Armando S, Effern M, Namkung Y, Jenkins L, Horn V, Stößel A, Dargatz H, Tietze D, Imhof D, Galés C, Drewke C, Müller CE, Hölzel M, Milligan G, Tobin AB, Gomeza J, Dohlman HG, Sondek J, Harden TK, Bouvier M, Laporte SA, Aoki J, Fleischmann BK, Mohr K, König GM, Tüting T, Kostenis E. Schrage R, et al. Among authors: stossel a. Nat Commun. 2015 Dec 14;6:10156. doi: 10.1038/ncomms10156. Nat Commun. 2015. PMID: 26658454 Free PMC article.
18 results