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Voltage gated sodium channels as drug discovery targets.
Bagal SK, Marron BE, Owen RM, Storer RI, Swain NA. Bagal SK, et al. Among authors: storer ri. Channels (Austin). 2015;9(6):360-6. doi: 10.1080/19336950.2015.1079674. Channels (Austin). 2015. PMID: 26646477 Free PMC article. Review.
Ion channels as therapeutic targets: a drug discovery perspective.
Bagal SK, Brown AD, Cox PJ, Omoto K, Owen RM, Pryde DC, Sidders B, Skerratt SE, Stevens EB, Storer RI, Swain NA. Bagal SK, et al. Among authors: storer ri. J Med Chem. 2013 Feb 14;56(3):593-624. doi: 10.1021/jm3011433. Epub 2012 Nov 29. J Med Chem. 2013. PMID: 23121096 Review.
Recent progress in sodium channel modulators for pain.
Bagal SK, Chapman ML, Marron BE, Prime R, Storer RI, Swain NA. Bagal SK, et al. Among authors: storer ri. Bioorg Med Chem Lett. 2014 Aug 15;24(16):3690-9. doi: 10.1016/j.bmcl.2014.06.038. Epub 2014 Jun 21. Bioorg Med Chem Lett. 2014. PMID: 25060923 Free article. Review.
Discovery of Clinical Candidate 4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of NaV1.7.
Swain NA, Batchelor D, Beaudoin S, Bechle BM, Bradley PA, Brown AD, Brown B, Butcher KJ, Butt RP, Chapman ML, Denton S, Ellis D, Galan SRG, Gaulier SM, Greener BS, de Groot MJ, Glossop MS, Gurrell IK, Hannam J, Johnson MS, Lin Z, Markworth CJ, Marron BE, Millan DS, Nakagawa S, Pike A, Printzenhoff D, Rawson DJ, Ransley SJ, Reister SM, Sasaki K, Storer RI, Stupple PA, West CW. Swain NA, et al. Among authors: storer ri. J Med Chem. 2017 Aug 24;60(16):7029-7042. doi: 10.1021/acs.jmedchem.7b00598. Epub 2017 Aug 10. J Med Chem. 2017. PMID: 28682065
Highly potent and selective NaV1.7 inhibitors for use as intravenous agents and chemical probes.
Storer RI, Pike A, Swain NA, Alexandrou AJ, Bechle BM, Blakemore DC, Brown AD, Castle NA, Corbett MS, Flanagan NJ, Fengas D, Johnson MS, Jones LH, Marron BE, Payne CE, Printzenhoff D, Rawson DJ, Rose CR, Ryckmans T, Sun J, Theile JW, Torella R, Tseng E, Warmus JS. Storer RI, et al. Bioorg Med Chem Lett. 2017 Nov 1;27(21):4805-4811. doi: 10.1016/j.bmcl.2017.09.056. Epub 2017 Sep 28. Bioorg Med Chem Lett. 2017. PMID: 29029933
Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release.
Alexandrou AJ, Brown AR, Chapman ML, Estacion M, Turner J, Mis MA, Wilbrey A, Payne EC, Gutteridge A, Cox PJ, Doyle R, Printzenhoff D, Lin Z, Marron BE, West C, Swain NA, Storer RI, Stupple PA, Castle NA, Hounshell JA, Rivara M, Randall A, Dib-Hajj SD, Krafte D, Waxman SG, Patel MK, Butt RP, Stevens EB. Alexandrou AJ, et al. Among authors: storer ri. PLoS One. 2016 Apr 6;11(4):e0152405. doi: 10.1371/journal.pone.0152405. eCollection 2016. PLoS One. 2016. PMID: 27050761 Free PMC article.
Targeting the cAMP and Transforming Growth Factor-β Pathway Increases Proliferation to Promote Re-Epithelialization of Human Stem Cell-Derived Retinal Pigment Epithelium.
Choudhary P, Gutteridge A, Impey E, Storer RI, Owen RM, Whiting PJ, Bictash M, Benn CL. Choudhary P, et al. Among authors: storer ri. Stem Cells Transl Med. 2016 Jul;5(7):925-37. doi: 10.5966/sctm.2015-0247. Epub 2016 Apr 25. Stem Cells Transl Med. 2016. PMID: 27112176 Free PMC article.
Discovery of Compounds that Positively Modulate the High Affinity Choline Transporter.
Choudhary P, Armstrong EJ, Jorgensen CC, Piotrowski M, Barthmes M, Torella R, Johnston SE, Maruyama Y, Janiszewski JS, Storer RI, Skerratt SE, Benn CL. Choudhary P, et al. Among authors: storer ri. Front Mol Neurosci. 2017 Feb 27;10:40. doi: 10.3389/fnmol.2017.00040. eCollection 2017. Front Mol Neurosci. 2017. PMID: 28289374 Free PMC article.
66 results