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A specific nanobody prevents amyloidogenesis of D76N β2-microglobulin in vitro and modifies its tissue distribution in vivo.
Raimondi S, Porcari R, Mangione PP, Verona G, Marcoux J, Giorgetti S, Taylor GW, Ellmerich S, Ballico M, Zanini S, Pardon E, Al-Shawi R, Simons JP, Corazza A, Fogolari F, Leri M, Stefani M, Bucciantini M, Gillmore JD, Hawkins PN, Valli M, Stoppini M, Robinson CV, Steyaert J, Esposito G, Bellotti V. Raimondi S, et al. Among authors: stoppini m. Sci Rep. 2017 Apr 21;7:46711. doi: 10.1038/srep46711. Sci Rep. 2017. PMID: 28429761 Free PMC article.
Effect of tetracyclines on the dynamics of formation and destructuration of beta2-microglobulin amyloid fibrils.
Giorgetti S, Raimondi S, Pagano K, Relini A, Bucciantini M, Corazza A, Fogolari F, Codutti L, Salmona M, Mangione P, Colombo L, De Luigi A, Porcari R, Gliozzi A, Stefani M, Esposito G, Bellotti V, Stoppini M. Giorgetti S, et al. Among authors: stoppini m. J Biol Chem. 2011 Jan 21;286(3):2121-31. doi: 10.1074/jbc.M110.178376. Epub 2010 Nov 10. J Biol Chem. 2011. PMID: 21068391 Free PMC article.
Structure, folding dynamics, and amyloidogenesis of D76N β2-microglobulin: roles of shear flow, hydrophobic surfaces, and α-crystallin.
Mangione PP, Esposito G, Relini A, Raimondi S, Porcari R, Giorgetti S, Corazza A, Fogolari F, Penco A, Goto Y, Lee YH, Yagi H, Cecconi C, Naqvi MM, Gillmore JD, Hawkins PN, Chiti F, Rolandi R, Taylor GW, Pepys MB, Stoppini M, Bellotti V. Mangione PP, et al. Among authors: stoppini m. J Biol Chem. 2013 Oct 25;288(43):30917-30. doi: 10.1074/jbc.M113.498857. Epub 2013 Sep 6. J Biol Chem. 2013. PMID: 24014031 Free PMC article.
Systemic amyloidosis: lessons from β2-microglobulin.
Stoppini M, Bellotti V. Stoppini M, et al. J Biol Chem. 2015 Apr 17;290(16):9951-8. doi: 10.1074/jbc.R115.639799. Epub 2015 Mar 6. J Biol Chem. 2015. PMID: 25750126 Free PMC article. Review.
Plasminogen activation triggers transthyretin amyloidogenesis in vitro.
Mangione PP, Verona G, Corazza A, Marcoux J, Canetti D, Giorgetti S, Raimondi S, Stoppini M, Esposito M, Relini A, Canale C, Valli M, Marchese L, Faravelli G, Obici L, Hawkins PN, Taylor GW, Gillmore JD, Pepys MB, Bellotti V. Mangione PP, et al. Among authors: stoppini m. J Biol Chem. 2018 Sep 14;293(37):14192-14199. doi: 10.1074/jbc.RA118.003990. Epub 2018 Jul 17. J Biol Chem. 2018. PMID: 30018138 Free PMC article.
Properties of some variants of human beta2-microglobulin and amyloidogenesis.
Corazza A, Pettirossi F, Viglino P, Verdone G, Garcia J, Dumy P, Giorgetti S, Mangione P, Raimondi S, Stoppini M, Bellotti V, Esposito G. Corazza A, et al. Among authors: stoppini m. J Biol Chem. 2004 Mar 5;279(10):9176-89. doi: 10.1074/jbc.M310779200. Epub 2003 Dec 4. J Biol Chem. 2004. PMID: 14660575 Free article.
Beta2-microglobulin isoforms display an heterogeneous affinity for type I collagen.
Giorgetti S, Rossi A, Mangione P, Raimondi S, Marini S, Stoppini M, Corazza A, Viglino P, Esposito G, Cetta G, Merlini G, Bellotti V. Giorgetti S, et al. Among authors: stoppini m. Protein Sci. 2005 Mar;14(3):696-702. doi: 10.1110/ps.041194005. Epub 2005 Feb 2. Protein Sci. 2005. PMID: 15689502 Free PMC article.
Lysine 58-cleaved beta2-microglobulin is not detectable by 2D electrophoresis in ex vivo amyloid fibrils of two patients affected by dialysis-related amyloidosis.
Giorgetti S, Stoppini M, Tennent GA, Relini A, Marchese L, Raimondi S, Monti M, Marini S, Østergaard O, Heegaard NH, Pucci P, Esposito G, Merlini G, Bellotti V. Giorgetti S, et al. Among authors: stoppini m. Protein Sci. 2007 Feb;16(2):343-9. doi: 10.1110/ps.062563507. Protein Sci. 2007. PMID: 17242436 Free PMC article.
The controlling roles of Trp60 and Trp95 in beta2-microglobulin function, folding and amyloid aggregation properties.
Esposito G, Ricagno S, Corazza A, Rennella E, Gümral D, Mimmi MC, Betto E, Pucillo CE, Fogolari F, Viglino P, Raimondi S, Giorgetti S, Bolognesi B, Merlini G, Stoppini M, Bolognesi M, Bellotti V. Esposito G, et al. Among authors: stoppini m. J Mol Biol. 2008 May 9;378(4):887-97. doi: 10.1016/j.jmb.2008.03.002. Epub 2008 Mar 8. J Mol Biol. 2008. PMID: 18395224
84 results