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Disulfiram causes selective hypoxic cancer cell toxicity and radio-chemo-sensitization via redox cycling of copper.
Falls-Hubert KC, Butler AL, Gui K, Anderson M, Li M, Stolwijk JM, Rodman SN 3rd, Solst SR, Tomanek-Chalkley A, Searby CC, Sheffield VC, Sandfort V, Schmidt H, McCormick ML, Wels BR, Allen BG, Buettner GR, Schultz MK, Spitz DR. Falls-Hubert KC, et al. Among authors: stolwijk jm. Free Radic Biol Med. 2020 Apr;150:1-11. doi: 10.1016/j.freeradbiomed.2020.01.186. Epub 2020 Feb 4. Free Radic Biol Med. 2020. PMID: 32032663 Free PMC article.
Pharmacological ascorbate as a novel therapeutic strategy to enhance cancer immunotherapy.
Zaher A, Stephens LM, Miller AM, Hartwig SM, Stolwijk JM, Petronek MS, Zacharias ZR, Wadas TJ, Monga V, Cullen JJ, Furqan M, Houtman JCD, Varga SM, Spitz DR, Allen BG. Zaher A, et al. Among authors: stolwijk jm. Front Immunol. 2022 Aug 22;13:989000. doi: 10.3389/fimmu.2022.989000. eCollection 2022. Front Immunol. 2022. PMID: 36072595 Free PMC article. Review.
Magnetite nanoparticles as a kinetically favorable source of iron to enhance GBM response to chemoradiosensitization with pharmacological ascorbate.
Petronek MS, Teferi N, Caster JM, Stolwijk JM, Zaher A, Buatti JM, Hasan D, Wafa EI, Salem AK, Gillan EG, St-Aubin JJ, Buettner GR, Spitz DR, Magnotta VA, Allen BG. Petronek MS, et al. Among authors: stolwijk jm. Redox Biol. 2023 Jun;62:102651. doi: 10.1016/j.redox.2023.102651. Epub 2023 Mar 7. Redox Biol. 2023. PMID: 36924683 Free PMC article.
Magnetic Resonance Imaging of Iron Metabolism with T2* Mapping Predicts an Enhanced Clinical Response to Pharmacologic Ascorbate in Patients with GBM.
Petronek MS, Monga V, Bodeker KL, Kwofie M, Lee CY, Mapuskar KA, Stolwijk JM, Zaher A, Wagner BA, Smith MC, Vollstedt S, Brown H, Chandler ML, Lorack AC, Wulfekuhle JS, Sarkaria JN, Flynn RT, Greenlee JDW, Howard MA, Smith BJ, Jones KA, Buettner GR, Cullen JJ, St-Aubin J, Buatti JM, Magnotta VA, Spitz DR, Allen BG. Petronek MS, et al. Among authors: stolwijk jm. Clin Cancer Res. 2024 Jan 17;30(2):283-293. doi: 10.1158/1078-0432.CCR-22-3952. Clin Cancer Res. 2024. PMID: 37773633 Clinical Trial.
Depletion of Labile Iron Induces Replication Stress and Enhances Responses to Chemoradiation in Non-Small-Cell Lung Cancer.
Bayanbold K, Singhania M, Fath MA, Searby CC, Stolwijk JM, Henrich JB, Pulliam CF, Schoenfeld JD, Mapuskar KA, Sho S, Caster JM, Allen BG, Buettner GR, Spies M, Goswami PC, Petronek MS, Spitz DR. Bayanbold K, et al. Among authors: stolwijk jm. Antioxidants (Basel). 2023 Nov 15;12(11):2005. doi: 10.3390/antiox12112005. Antioxidants (Basel). 2023. PMID: 38001858 Free PMC article.
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