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Disulfiram causes selective hypoxic cancer cell toxicity and radio-chemo-sensitization via redox cycling of copper.
Falls-Hubert KC, Butler AL, Gui K, Anderson M, Li M, Stolwijk JM, Rodman SN 3rd, Solst SR, Tomanek-Chalkley A, Searby CC, Sheffield VC, Sandfort V, Schmidt H, McCormick ML, Wels BR, Allen BG, Buettner GR, Schultz MK, Spitz DR. Falls-Hubert KC, et al. Free Radic Biol Med. 2020 Apr;150:1-11. doi: 10.1016/j.freeradbiomed.2020.01.186. Epub 2020 Feb 4. Free Radic Biol Med. 2020. PMID: 32032663 Free PMC article.
Pharmacological ascorbate as a novel therapeutic strategy to enhance cancer immunotherapy.
Zaher A, Stephens LM, Miller AM, Hartwig SM, Stolwijk JM, Petronek MS, Zacharias ZR, Wadas TJ, Monga V, Cullen JJ, Furqan M, Houtman JCD, Varga SM, Spitz DR, Allen BG. Zaher A, et al. Among authors: stolwijk jm. Front Immunol. 2022 Aug 22;13:989000. doi: 10.3389/fimmu.2022.989000. eCollection 2022. Front Immunol. 2022. PMID: 36072595 Free PMC article. Review.
Dual Oxidase-Induced Sustained Generation of Hydrogen Peroxide Contributes to Pharmacologic Ascorbate-Induced Cytotoxicity.
Gibson AR, O'Leary BR, Du J, Sarsour EH, Kalen AL, Wagner BA, Stolwijk JM, Falls-Hubert KC, Alexander MS, Carroll RS, Spitz DR, Buettner GR, Goswami PC, Cullen JJ. Gibson AR, et al. Among authors: stolwijk jm. Cancer Res. 2020 Apr 1;80(7):1401-1413. doi: 10.1158/0008-5472.CAN-19-3094. Epub 2020 Feb 10. Cancer Res. 2020. PMID: 32041838 Free PMC article.
143 results