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Reengineering the specificity of the highly selective Clostridium botulinum protease via directed evolution.
Dyer RP, Isoda HM, Salcedo GS, Speciale G, Fletcher MH, Le LQ, Liu Y, Brami-Cherrier K, Malik SZ, Vazquez-Cintron EJ, Chu AC, Rupp DC, Jacky BPS, Nguyen TTM, Katz BB, Steward LE, Majumdar S, Brideau-Andersen AD, Weiss GA. Dyer RP, et al. Among authors: steward le. Sci Rep. 2022 Jun 15;12(1):9956. doi: 10.1038/s41598-022-13617-z. Sci Rep. 2022. PMID: 35705606 Free PMC article.
Novel Native and Engineered Botulinum Neurotoxins.
Steward L, Brin MF, Brideau-Andersen A. Steward L, et al. Handb Exp Pharmacol. 2021;263:63-89. doi: 10.1007/164_2020_351. Handb Exp Pharmacol. 2021. PMID: 32274579 Review.
OnabotulinumtoxinA Displays Greater Biological Activity Compared to IncobotulinumtoxinA, Demonstrating Non-Interchangeability in Both In Vitro and In Vivo Assays.
Rupp D, Nicholson G, Canty D, Wang J, Rhéaume C, Le L, Steward LE, Washburn M, Jacky BP, Broide RS, Philipp-Dormston WG, Brin MF, Brideau-Andersen A. Rupp D, et al. Among authors: steward le. Toxins (Basel). 2020 Jun 13;12(6):393. doi: 10.3390/toxins12060393. Toxins (Basel). 2020. PMID: 32545832 Free PMC article.
Plasma membrane localization signals in the light chain of botulinum neurotoxin.
Fernández-Salas E, Steward LE, Ho H, Garay PE, Sun SW, Gilmore MA, Ordas JV, Wang J, Francis J, Aoki KR. Fernández-Salas E, et al. Among authors: steward le. Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3208-13. doi: 10.1073/pnas.0400229101. Epub 2004 Feb 24. Proc Natl Acad Sci U S A. 2004. PMID: 14982988 Free PMC article.
24 results