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A noncompetitive small molecule inhibitor of estrogen-regulated gene expression and breast cancer cell growth that enhances proteasome-dependent degradation of estrogen receptor {alpha}.
Kretzer NM, Cherian MT, Mao C, Aninye IO, Reynolds PD, Schiff R, Hergenrother PJ, Nordeen SK, Wilson EM, Shapiro DJ. Kretzer NM, et al. Among authors: nordeen sk. J Biol Chem. 2010 Dec 31;285(53):41863-73. doi: 10.1074/jbc.M110.183723. Epub 2010 Nov 1. J Biol Chem. 2010. PMID: 21041310 Free PMC article.
A new small molecule inhibitor of estrogen receptor alpha binding to estrogen response elements blocks estrogen-dependent growth of cancer cells.
Mao C, Patterson NM, Cherian MT, Aninye IO, Zhang C, Montoya JB, Cheng J, Putt KS, Hergenrother PJ, Wilson EM, Nardulli AM, Nordeen SK, Shapiro DJ. Mao C, et al. Among authors: nordeen sk. J Biol Chem. 2008 May 9;283(19):12819-30. doi: 10.1074/jbc.M709936200. Epub 2008 Mar 12. J Biol Chem. 2008. PMID: 18337247 Free PMC article.
24 results