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Structural basis of the acyl-transfer mechanism of human GPAT1.
Johnson ZL, Ammirati M, Wasilko DJ, Chang JS, Noell S, Foley TL, Yoon H, Smith K, Asano S, Hales K, Wan M, Yang Q, Piotrowski MA, Farley KA, Gilbert T, Aschenbrenner LM, Fennell KF, Dutra JK, Xu M, Guo C, Varghese AE, Bellenger J, Quinn A, Am Ende CW, West GM, Griffor MC, Bennett D, Calabrese M, Steppan CM, Han S, Wu H. Johnson ZL, et al. Among authors: steppan cm. Nat Struct Mol Biol. 2023 Jan;30(1):22-30. doi: 10.1038/s41594-022-00884-7. Epub 2022 Dec 15. Nat Struct Mol Biol. 2023. PMID: 36522428
A Second-Generation Oral SARS-CoV-2 Main Protease Inhibitor Clinical Candidate for the Treatment of COVID-19.
Allerton CMN, Arcari JT, Aschenbrenner LM, Avery M, Bechle BM, Behzadi MA, Boras B, Buzon LM, Cardin RD, Catlin NR, Carlo AA, Coffman KJ, Dantonio A, Di L, Eng H, Farley KA, Ferre RA, Gernhardt SS, Gibson SA, Greasley SE, Greenfield SR, Hurst BL, Kalgutkar AS, Kimoto E, Lanyon LF, Lovett GH, Lian Y, Liu W, Martínez Alsina LA, Noell S, Obach RS, Owen DR, Patel NC, Rai DK, Reese MR, Rothan HA, Sakata S, Sammons MF, Sathish JG, Sharma R, Steppan CM, Tuttle JB, Verhoest PR, Wei L, Yang Q, Yurgelonis I, Zhu Y. Allerton CMN, et al. Among authors: steppan cm. J Med Chem. 2024 Apr 30. doi: 10.1021/acs.jmedchem.3c02469. Online ahead of print. J Med Chem. 2024. PMID: 38687966
Accelerating SLC Transporter Research: Streamlining Knowledge and Validated Tools.
Wiedmer T, Ingles-Prieto A, Goldmann U, Steppan CM, Superti-Furga G; RESOLUTE, REsolution consortia. Wiedmer T, et al. Among authors: steppan cm. Clin Pharmacol Ther. 2022 Sep;112(3):439-442. doi: 10.1002/cpt.2639. Epub 2022 Aug 8. Clin Pharmacol Ther. 2022. PMID: 35938294 Free PMC article. No abstract available.
Discovery of Small-Molecule CD33 Pre-mRNA Splicing Modulators.
Chappie TA, Abdelmessih M, Ambroise CW, Boehm M, Cai M, Green M, Guilmette E, Steppan CM, Stevens LM, Wei L, Xi S, Hasson SA. Chappie TA, et al. Among authors: steppan cm. ACS Med Chem Lett. 2022 Jan 4;13(1):55-62. doi: 10.1021/acsmedchemlett.1c00396. eCollection 2022 Jan 13. ACS Med Chem Lett. 2022. PMID: 35059124 Free PMC article.
An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19.
Owen DR, Allerton CMN, Anderson AS, Aschenbrenner L, Avery M, Berritt S, Boras B, Cardin RD, Carlo A, Coffman KJ, Dantonio A, Di L, Eng H, Ferre R, Gajiwala KS, Gibson SA, Greasley SE, Hurst BL, Kadar EP, Kalgutkar AS, Lee JC, Lee J, Liu W, Mason SW, Noell S, Novak JJ, Obach RS, Ogilvie K, Patel NC, Pettersson M, Rai DK, Reese MR, Sammons MF, Sathish JG, Singh RSP, Steppan CM, Stewart AE, Tuttle JB, Updyke L, Verhoest PR, Wei L, Yang Q, Zhu Y. Owen DR, et al. Among authors: steppan cm. Science. 2021 Dec 24;374(6575):1586-1593. doi: 10.1126/science.abl4784. Epub 2021 Nov 2. Science. 2021. PMID: 34726479 Free article.
An Overview of Cell-Based Assay Platforms for the Solute Carrier Family of Transporters.
Dvorak V, Wiedmer T, Ingles-Prieto A, Altermatt P, Batoulis H, Bärenz F, Bender E, Digles D, Dürrenberger F, Heitman LH, IJzerman AP, Kell DB, Kickinger S, Körzö D, Leippe P, Licher T, Manolova V, Rizzetto R, Sassone F, Scarabottolo L, Schlessinger A, Schneider V, Sijben HJ, Steck AL, Sundström H, Tremolada S, Wilhelm M, Wright Muelas M, Zindel D, Steppan CM, Superti-Furga G. Dvorak V, et al. Among authors: steppan cm. Front Pharmacol. 2021 Aug 10;12:722889. doi: 10.3389/fphar.2021.722889. eCollection 2021. Front Pharmacol. 2021. PMID: 34447313 Free PMC article. Review.
Acoustic Ejection Mass Spectrometry for High-Throughput Analysis.
Zhang H, Liu C, Hua W, Ghislain LP, Liu J, Aschenbrenner L, Noell S, Dirico KJ, Lanyon LF, Steppan CM, West M, Arnold DW, Covey TR, Datwani SS, Troutman MD. Zhang H, et al. Among authors: steppan cm. Anal Chem. 2021 Aug 10;93(31):10850-10861. doi: 10.1021/acs.analchem.1c01137. Epub 2021 Jul 28. Anal Chem. 2021. PMID: 34320311 Free article.
Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19.
Hoffman RL, Kania RS, Brothers MA, Davies JF, Ferre RA, Gajiwala KS, He M, Hogan RJ, Kozminski K, Li LY, Lockner JW, Lou J, Marra MT, Mitchell LJ Jr, Murray BW, Nieman JA, Noell S, Planken SP, Rowe T, Ryan K, Smith GJ 3rd, Solowiej JE, Steppan CM, Taggart B. Hoffman RL, et al. Among authors: steppan cm. J Med Chem. 2020 Nov 12;63(21):12725-12747. doi: 10.1021/acs.jmedchem.0c01063. Epub 2020 Oct 15. J Med Chem. 2020. PMID: 33054210
39 results