Stemmer WP - Search Results

1

Multivalent avimer proteins evolved by exon shuffling of a family of human receptor domains.

Silverman J, Liu Q, Bakker A, To W, Duguay A, Alba BM, Smith R, Rivas A, Li P, Le H, Whitehorn E, Moore KW, Swimmer C, Perlroth V, Vogt M, Kolkman J, Stemmer WP. Silverman J, et al. Among authors: stemmer wp. Nat Biotechnol. 2005 Dec;23(12):1556-61. doi: 10.1038/nbt1166. Epub 2005 Nov 20. Nat Biotechnol. 2005. PMID: 16299519

2

Affinity selective isolation of ligands from peptide libraries through display on a lac repressor "headpiece dimer".

Gates CM, Stemmer WP, Kaptein R, Schatz PJ. Gates CM, et al. Among authors: stemmer wp. J Mol Biol. 1996 Jan 26;255(3):373-86. doi: 10.1006/jmbi.1996.0031. J Mol Biol. 1996. PMID: 8568883

3

GLP2-2G-XTEN: a pharmaceutical protein with improved serum half-life and efficacy in a rat Crohn's. PLoS One. 2012; 7(11): e50630.

Alters SE, McLaughlin B, Spink B, Lachinyan T, Wang CW, Podust V, Schellenberger V, Stemmer WP. Alters SE, et al. Among authors: stemmer wp. PLoS One. 2013 Jun 10;8(6):10.1371/annotation/5c7138bd-5602-466d-8daf-e75e0b7d7fdb. doi: 10.1371/annotation/5c7138bd-5602-466d-8daf-e75e0b7d7fdb. Print 2013. PLoS One. 2013. PMID: 23762221 Free PMC article.

4

GLP2-2G-XTEN: a pharmaceutical protein with improved serum half-life and efficacy in a rat Crohn's disease model.

Alters SE, McLaughlin B, Spink B, Lachinyan T, Wang CW, Podust V, Schellenberger V, Stemmer WP. Alters SE, et al. Among authors: stemmer wp. PLoS One. 2012;7(11):e50630. doi: 10.1371/journal.pone.0050630. Epub 2012 Nov 26. PLoS One. 2012. PMID: 23189208 Free PMC article.

5

A novel long-acting human growth hormone fusion protein (VRS-317): enhanced in vivo potency and half-life.

Cleland JL, Geething NC, Moore JA, Rogers BC, Spink BJ, Wang CW, Alters SE, Stemmer WP, Schellenberger V. Cleland JL, et al. Among authors: stemmer wp. J Pharm Sci. 2012 Aug;101(8):2744-54. doi: 10.1002/jps.23229. Epub 2012 Jun 7. J Pharm Sci. 2012. PMID: 22678811 Free PMC article.

6

Gcg-XTEN: an improved glucagon capable of preventing hypoglycemia without increasing baseline blood glucose.

Geething NC, To W, Spink BJ, Scholle MD, Wang CW, Yin Y, Yao Y, Schellenberger V, Cleland JL, Stemmer WP, Silverman J. Geething NC, et al. Among authors: stemmer wp. PLoS One. 2010 Apr 14;5(4):e10175. doi: 10.1371/journal.pone.0010175. PLoS One. 2010. PMID: 20418955 Free PMC article.

7

A recombinant polypeptide extends the in vivo half-life of peptides and proteins in a tunable manner.

Schellenberger V, Wang CW, Geething NC, Spink BJ, Campbell A, To W, Scholle MD, Yin Y, Yao Y, Bogin O, Cleland JL, Silverman J, Stemmer WP. Schellenberger V, et al. Among authors: stemmer wp. Nat Biotechnol. 2009 Dec;27(12):1186-90. doi: 10.1038/nbt.1588. Nat Biotechnol. 2009. PMID: 19915550

8

Diverse plasmid DNA vectors by directed molecular evolution of cytomegalovirus promoters.

Wright A, Semyonov A, Dawes G, Crameri A, Lyons R, Stemmer WP, Apt D, Punnonen J. Wright A, et al. Among authors: stemmer wp. Hum Gene Ther. 2005 Jul;16(7):881-92. doi: 10.1089/hum.2005.16.881. Hum Gene Ther. 2005. PMID: 16000069

9

Optimized expression and specific activity of IL-12 by directed molecular evolution.

Leong SR, Chang JC, Ong R, Dawes G, Stemmer WP, Punnonen J. Leong SR, et al. Among authors: stemmer wp. Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1163-8. doi: 10.1073/pnas.0237327100. Epub 2003 Jan 15. Proc Natl Acad Sci U S A. 2003. PMID: 12529500 Free PMC article.

10

Directed Evolution and Biocatalysis.

Powell KA, Ramer SW, Del Cardayré SB, Stemmer WP, Tobin MB, Longchamp PF, Huisman GW. Powell KA, et al. Among authors: stemmer wp. Angew Chem Int Ed Engl. 2001 Nov 5;40(21):3948-3959. doi: 10.1002/1521-3773(20011105)40:21<3948::aid-anie3948>3.0.co;2-n. Angew Chem Int Ed Engl. 2001. PMID: 12404465

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