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A non-coding variant linked to metabolic obesity with normal weight affects actin remodelling in subcutaneous adipocytes.
Glunk V, Laber S, Sinnott-Armstrong N, Sobreira DR, Strobel SM, Batista TM, Kubitz P, Moud BN, Ebert H, Huang Y, Brandl B, Garbo G, Honecker J, Stirling DR, Abdennur N, Calabuig-Navarro V, Skurk T, Ocvirk S, Stemmer K, Cimini BA, Carpenter AE, Dankel SN, Lindgren CM, Hauner H, Nobrega MA, Claussnitzer M. Glunk V, et al. Among authors: stemmer k. Nat Metab. 2023 May;5(5):861-879. doi: 10.1038/s42255-023-00807-w. Epub 2023 May 30. Nat Metab. 2023. PMID: 37253881
Adipocyte-derived extracellular vesicles increase insulin secretion through transport of insulinotropic protein cargo.
Kulaj K, Harger A, Bauer M, Caliskan ÖS, Gupta TK, Chiang DM, Milbank E, Reber J, Karlas A, Kotzbeck P, Sailer DN, Volta F, Lutter D, Prakash S, Merl-Pham J, Ntziachristos V, Hauner H, Pfaffl MW, Tschöp MH, Müller TD, Hauck SM, Engel BD, Gerdes JM, Pfluger PT, Krahmer N, Stemmer K. Kulaj K, et al. Among authors: stemmer k. Nat Commun. 2023 Feb 9;14(1):709. doi: 10.1038/s41467-023-36148-1. Nat Commun. 2023. PMID: 36759608 Free PMC article.
GLP-1-mediated delivery of tesaglitazar improves obesity and glucose metabolism in male mice.
Quarta C, Stemmer K, Novikoff A, Yang B, Klingelhuber F, Harger A, Bakhti M, Bastidas-Ponce A, Baugé E, Campbell JE, Capozzi M, Clemmensen C, Collden G, Cota P, Douros J, Drucker DJ, DuBois B, Feuchtinger A, Garcia-Caceres C, Grandl G, Hennuyer N, Herzig S, Hofmann SM, Knerr PJ, Kulaj K, Lalloyer F, Lickert H, Liskiewicz A, Liskiewicz D, Maity G, Perez-Tilve D, Prakash S, Sanchez-Garrido MA, Zhang Q, Staels B, Krahmer N, DiMarchi RD, Tschöp MH, Finan B, Müller TD. Quarta C, et al. Among authors: stemmer k. Nat Metab. 2022 Aug;4(8):1071-1083. doi: 10.1038/s42255-022-00617-6. Epub 2022 Aug 22. Nat Metab. 2022. PMID: 35995995 Free PMC article.
Adipose cells and tissues soften with lipid accumulation while in diabetes adipose tissue stiffens.
Abuhattum S, Kotzbeck P, Schlüßler R, Harger A, Ariza de Schellenberger A, Kim K, Escolano JC, Müller T, Braun J, Wabitsch M, Tschöp M, Sack I, Brankatschk M, Guck J, Stemmer K, Taubenberger AV. Abuhattum S, et al. Among authors: stemmer k. Sci Rep. 2022 Jun 20;12(1):10325. doi: 10.1038/s41598-022-13324-9. Sci Rep. 2022. PMID: 35725987 Free PMC article.
Diet-induced alteration of intestinal stem cell function underlies obesity and prediabetes in mice.
Aliluev A, Tritschler S, Sterr M, Oppenländer L, Hinterdobler J, Greisle T, Irmler M, Beckers J, Sun N, Walch A, Stemmer K, Kindt A, Krumsiek J, Tschöp MH, Luecken MD, Theis FJ, Lickert H, Böttcher A. Aliluev A, et al. Among authors: stemmer k. Nat Metab. 2021 Sep;3(9):1202-1216. doi: 10.1038/s42255-021-00458-9. Epub 2021 Sep 22. Nat Metab. 2021. PMID: 34552271 Free PMC article.
Vertical sleeve gastrectomy triggers fast β-cell recovery upon overt diabetes.
Oppenländer L, Palit S, Stemmer K, Greisle T, Sterr M, Salinno C, Bastidas-Ponce A, Feuchtinger A, Böttcher A, Ansarullah, Theis FJ, Lickert H. Oppenländer L, et al. Among authors: stemmer k. Mol Metab. 2021 Dec;54:101330. doi: 10.1016/j.molmet.2021.101330. Epub 2021 Sep 6. Mol Metab. 2021. PMID: 34500108 Free PMC article.
The glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling.
Zhang Q, Delessa CT, Augustin R, Bakhti M, Colldén G, Drucker DJ, Feuchtinger A, Caceres CG, Grandl G, Harger A, Herzig S, Hofmann S, Holleman CL, Jastroch M, Keipert S, Kleinert M, Knerr PJ, Kulaj K, Legutko B, Lickert H, Liu X, Luippold G, Lutter D, Malogajski E, Medina MT, Mowery SA, Blutke A, Perez-Tilve D, Salinno C, Sehrer L, DiMarchi RD, Tschöp MH, Stemmer K, Finan B, Wolfrum C, Müller TD. Zhang Q, et al. Among authors: stemmer k. Cell Metab. 2021 Apr 6;33(4):833-844.e5. doi: 10.1016/j.cmet.2021.01.015. Epub 2021 Feb 10. Cell Metab. 2021. PMID: 33571454 Free PMC article.
Spatiotemporal GLP-1 and GIP receptor signaling and trafficking/recycling dynamics induced by selected receptor mono- and dual-agonists.
Novikoff A, O'Brien SL, Bernecker M, Grandl G, Kleinert M, Knerr PJ, Stemmer K, Klingenspor M, Zeigerer A, DiMarchi R, Tschöp MH, Finan B, Calebiro D, Müller TD. Novikoff A, et al. Among authors: stemmer k. Mol Metab. 2021 Jul;49:101181. doi: 10.1016/j.molmet.2021.101181. Epub 2021 Feb 6. Mol Metab. 2021. PMID: 33556643 Free PMC article.
102 results