Steinmetzer T - Search Results

1

OFF-State-Specific Inhibition of the Proprotein Convertase Furin.

Dahms SO, Haider T, Klebe G, Steinmetzer T, Brandstetter H. Dahms SO, et al. Among authors: steinmetzer t. ACS Chem Biol. 2021 Sep 17;16(9):1692-1700. doi: 10.1021/acschembio.1c00411. Epub 2021 Aug 20. ACS Chem Biol. 2021. PMID: 34415722 Free PMC article.

2

Potent inhibitors of furin and furin-like proprotein convertases containing decarboxylated P1 arginine mimetics.

Becker GL, Sielaff F, Than ME, Lindberg I, Routhier S, Day R, Lu Y, Garten W, Steinmetzer T. Becker GL, et al. Among authors: steinmetzer t. J Med Chem. 2010 Feb 11;53(3):1067-75. doi: 10.1021/jm9012455. J Med Chem. 2010. PMID: 20038105 Free PMC article.

3

New furin inhibitors based on weakly basic amidinohydrazones.

Sielaff F, Than ME, Bevec D, Lindberg I, Steinmetzer T. Sielaff F, et al. Among authors: steinmetzer t. Bioorg Med Chem Lett. 2011 Jan 15;21(2):836-40. doi: 10.1016/j.bmcl.2010.11.092. Epub 2010 Nov 25. Bioorg Med Chem Lett. 2011. PMID: 21168329 Free PMC article.

4

Highly potent inhibitors of proprotein convertase furin as potential drugs for treatment of infectious diseases.

Becker GL, Lu Y, Hardes K, Strehlow B, Levesque C, Lindberg I, Sandvig K, Bakowsky U, Day R, Garten W, Steinmetzer T. Becker GL, et al. Among authors: steinmetzer t. J Biol Chem. 2012 Jun 22;287(26):21992-2003. doi: 10.1074/jbc.M111.332643. Epub 2012 Apr 26. J Biol Chem. 2012. PMID: 22539349 Free PMC article.

5

Ligand binding stepwise disrupts water network in thrombin: enthalpic and entropic changes reveal classical hydrophobic effect.

Biela A, Sielaff F, Terwesten F, Heine A, Steinmetzer T, Klebe G. Biela A, et al. Among authors: steinmetzer t. J Med Chem. 2012 Jul 12;55(13):6094-110. doi: 10.1021/jm300337q. Epub 2012 Jun 25. J Med Chem. 2012. PMID: 22612268

6

Quantifying protein-ligand binding constants using electrospray ionization mass spectrometry: a systematic binding affinity study of a series of hydrophobically modified trypsin inhibitors.

Cubrilovic D, Biela A, Sielaff F, Steinmetzer T, Klebe G, Zenobi R. Cubrilovic D, et al. Among authors: steinmetzer t. J Am Soc Mass Spectrom. 2012 Oct;23(10):1768-77. doi: 10.1007/s13361-012-0451-6. Epub 2012 Aug 7. J Am Soc Mass Spectrom. 2012. PMID: 22869298

7

Beyond heparinization: design of highly potent thrombin inhibitors suitable for surface coupling.

Steinmetzer T, Baum B, Biela A, Klebe G, Nowak G, Bucha E. Steinmetzer T, et al. ChemMedChem. 2012 Nov;7(11):1965-73. doi: 10.1002/cmdc.201200292. Epub 2012 Aug 20. ChemMedChem. 2012. PMID: 22907907

8

Development of new cyclic plasmin inhibitors with excellent potency and selectivity.

Saupe SM, Leubner S, Betz M, Klebe G, Steinmetzer T. Saupe SM, et al. Among authors: steinmetzer t. J Med Chem. 2013 Feb 14;56(3):820-31. doi: 10.1021/jm3012917. Epub 2013 Jan 23. J Med Chem. 2013. PMID: 23294255

9

Identification of the first synthetic inhibitors of the type II transmembrane serine protease TMPRSS2 suitable for inhibition of influenza virus activation.

Meyer D, Sielaff F, Hammami M, Böttcher-Friebertshäuser E, Garten W, Steinmetzer T. Meyer D, et al. Among authors: steinmetzer t. Biochem J. 2013 Jun 1;452(2):331-43. doi: 10.1042/BJ20130101. Biochem J. 2013. PMID: 23527573

10

X-ray structures of human furin in complex with competitive inhibitors.

Dahms SO, Hardes K, Becker GL, Steinmetzer T, Brandstetter H, Than ME. Dahms SO, et al. Among authors: steinmetzer t. ACS Chem Biol. 2014 May 16;9(5):1113-8. doi: 10.1021/cb500087x. Epub 2014 Apr 1. ACS Chem Biol. 2014. PMID: 24666235 Free PMC article.

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