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Virus-induced senescence is a driver and therapeutic target in COVID-19.
Lee S, Yu Y, Trimpert J, Benthani F, Mairhofer M, Richter-Pechanska P, Wyler E, Belenki D, Kaltenbrunner S, Pammer M, Kausche L, Firsching TC, Dietert K, Schotsaert M, Martínez-Romero C, Singh G, Kunz S, Niemeyer D, Ghanem R, Salzer HJF, Paar C, Mülleder M, Uccellini M, Michaelis EG, Khan A, Lau A, Schönlein M, Habringer A, Tomasits J, Adler JM, Kimeswenger S, Gruber AD, Hoetzenecker W, Steinkellner H, Purfürst B, Motz R, Di Pierro F, Lamprecht B, Osterrieder N, Landthaler M, Drosten C, García-Sastre A, Langer R, Ralser M, Eils R, Reimann M, Fan DNY, Schmitt CA. Lee S, et al. Among authors: steinkellner h. Nature. 2021 Nov;599(7884):283-289. doi: 10.1038/s41586-021-03995-1. Epub 2021 Sep 13. Nature. 2021. PMID: 34517409
Plant-based biopharmaceutical engineering.
Eidenberger L, Kogelmann B, Steinkellner H. Eidenberger L, et al. Among authors: steinkellner h. Nat Rev Bioeng. 2023;1(6):426-439. doi: 10.1038/s44222-023-00044-6. Epub 2023 Mar 21. Nat Rev Bioeng. 2023. PMID: 37317690 Free PMC article. Review.
Highly active engineered IgG3 antibodies against SARS-CoV-2.
Kallolimath S, Sun L, Palt R, Stiasny K, Mayrhofer P, Gruber C, Kogelmann B, Chen Q, Steinkellner H. Kallolimath S, et al. Among authors: steinkellner h. Proc Natl Acad Sci U S A. 2021 Oct 1;118(42):e2107249118. doi: 10.1073/pnas.2107249118. Proc Natl Acad Sci U S A. 2021. PMID: 34599091 Free PMC article.
Therapeutic treatment of Marburg and Ravn virus infection in nonhuman primates with a human monoclonal antibody.
Mire CE, Geisbert JB, Borisevich V, Fenton KA, Agans KN, Flyak AI, Deer DJ, Steinkellner H, Bohorov O, Bohorova N, Goodman C, Hiatt A, Kim DH, Pauly MH, Velasco J, Whaley KJ, Crowe JE Jr, Zeitlin L, Geisbert TW. Mire CE, et al. Among authors: steinkellner h. Sci Transl Med. 2017 Apr 5;9(384):eaai8711. doi: 10.1126/scitranslmed.aai8711. Sci Transl Med. 2017. PMID: 28381540 Free PMC article.
The human anti-HIV antibodies 2F5, 2G12, and PG9 differ in their susceptibility to proteolytic degradation: down-regulation of endogenous serine and cysteine proteinase activities could improve antibody production in plant-based expression platforms.
Niemer M, Mehofer U, Torres Acosta JA, Verdianz M, Henkel T, Loos A, Strasser R, Maresch D, Rademacher T, Steinkellner H, Mach L. Niemer M, et al. Among authors: steinkellner h. Biotechnol J. 2014 Apr;9(4):493-500. doi: 10.1002/biot.201300207. Biotechnol J. 2014. PMID: 24478053 Free PMC article.
166 results