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Inhibitors of dual-specificity tyrosine phosphorylation-regulated kinases (DYRK) exert a strong anti-herpesviral activity.
Hutterer C, Milbradt J, Hamilton S, Zaja M, Leban J, Henry C, Vitt D, Steingruber M, Sonntag E, Zeitträger I, Bahsi H, Stamminger T, Rawlinson W, Strobl S, Marschall M. Hutterer C, et al. Among authors: steingruber m. Antiviral Res. 2017 Jul;143:113-121. doi: 10.1016/j.antiviral.2017.04.003. Epub 2017 Apr 9. Antiviral Res. 2017. PMID: 28400201
The chemical class of quinazoline compounds provides a core structure for the design of anticytomegaloviral kinase inhibitors.
Hutterer C, Hamilton S, Steingruber M, Zeitträger I, Bahsi H, Thuma N, Naing Z, Örfi Z, Örfi L, Socher E, Sticht H, Rawlinson W, Chou S, Haupt VJ, Marschall M. Hutterer C, et al. Among authors: steingruber m. Antiviral Res. 2016 Oct;134:130-143. doi: 10.1016/j.antiviral.2016.08.005. Epub 2016 Aug 8. Antiviral Res. 2016. PMID: 27515131
Patient-Derived Cytomegaloviruses with Different Ganciclovir Sensitivities from UL97 Mutation Retain Their Replication Efficiency and Some Kinase Activity In Vitro.
Wong DD, van Zuylen WJ, Hamilton ST, Steingruber M, Sonntag E, Marschall M, Rawlinson WD. Wong DD, et al. Among authors: steingruber m. Antimicrob Agents Chemother. 2019 Aug 23;63(9):e02425-18. doi: 10.1128/AAC.02425-18. Print 2019 Sep. Antimicrob Agents Chemother. 2019. PMID: 31262766 Free PMC article.
Phosphosite Analysis of the Cytomegaloviral mRNA Export Factor pUL69 Reveals Serines with Critical Importance for Recruitment of Cellular Proteins Pin1 and UAP56/URH49.
Thomas M, Müller R, Horn G, Bogdanow B, Imami K, Milbradt J, Steingruber M, Marschall M, Schilling EM, Fossen T, Stamminger T. Thomas M, et al. Among authors: steingruber m. J Virol. 2020 Mar 31;94(8):e02151-19. doi: 10.1128/JVI.02151-19. Print 2020 Mar 31. J Virol. 2020. PMID: 31969433 Free PMC article.
Facile access to potent antiviral quinazoline heterocycles with fluorescence properties via merging metal-free domino reactions.
Held FE, Guryev AA, Fröhlich T, Hampel F, Kahnt A, Hutterer C, Steingruber M, Bahsi H, von Bojničić-Kninski C, Mattes DS, Foertsch TC, Nesterov-Mueller A, Marschall M, Tsogoeva SB. Held FE, et al. Among authors: steingruber m. Nat Commun. 2017 May 2;8:15071. doi: 10.1038/ncomms15071. Nat Commun. 2017. PMID: 28462939 Free PMC article.
18 results