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Cullin-RING ligases employ geometrically optimized catalytic partners for substrate targeting.
Li J, Purser N, Liwocha J, Scott DC, Byers HA, Steigenberger B, Hill S, Tripathi-Giesgen I, Hinkle T, Hansen FM, Prabu JR, Radhakrishnan SK, Kirkpatrick DS, Reichermeier KM, Schulman BA, Kleiger G. Li J, et al. Among authors: steigenberger b. Mol Cell. 2024 Apr 4;84(7):1304-1320.e16. doi: 10.1016/j.molcel.2024.01.022. Epub 2024 Feb 20. Mol Cell. 2024. PMID: 38382526 Free PMC article.
Small leucine-rich proteoglycans inhibit CNS regeneration by modifying the structural and mechanical properties of the lesion environment.
Kolb J, Tsata V, John N, Kim K, Möckel C, Rosso G, Kurbel V, Parmar A, Sharma G, Karandasheva K, Abuhattum S, Lyraki O, Beck T, Müller P, Schlüßler R, Frischknecht R, Wehner A, Krombholz N, Steigenberger B, Beis D, Takeoka A, Blümcke I, Möllmert S, Singh K, Guck J, Kobow K, Wehner D. Kolb J, et al. Among authors: steigenberger b. Nat Commun. 2023 Oct 26;14(1):6814. doi: 10.1038/s41467-023-42339-7. Nat Commun. 2023. PMID: 37884489 Free PMC article.
Noncanonical assembly, neddylation and chimeric cullin-RING/RBR ubiquitylation by the 1.8 MDa CUL9 E3 ligase complex.
Horn-Ghetko D, Hopf LVM, Tripathi-Giesgen I, Du J, Kostrhon S, Vu DT, Beier V, Steigenberger B, Prabu JR, Stier L, Bruss EM, Mann M, Xiong Y, Schulman BA. Horn-Ghetko D, et al. Among authors: steigenberger b. Nat Struct Mol Biol. 2024 Apr 11. doi: 10.1038/s41594-024-01257-y. Online ahead of print. Nat Struct Mol Biol. 2024. PMID: 38605244
Synthesis and Structure Elucidation of Glutamyl-Queuosine.
Pichler A, Hillmeier M, Heiss M, Peev E, Xefteris S, Steigenberger B, Thoma I, Müller M, Borsò M, Imhof A, Carell T. Pichler A, et al. Among authors: steigenberger b. J Am Chem Soc. 2023 Nov 29;145(47):25528-25532. doi: 10.1021/jacs.3c10075. Epub 2023 Nov 15. J Am Chem Soc. 2023. PMID: 37967838 Free PMC article.
23 results