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Identification of Small Molecules that Modulate Mutant p53 Condensation.
Lemos C, Schulze L, Weiske J, Meyer H, Braeuer N, Barak N, Eberspächer U, Werbeck N, Stresemann C, Lange M, Lesche R, Zablowsky N, Juenemann K, Kamburov A, Luh LM, Leissing TM, Mortier J, Steckel M, Steuber H, Eis K, Eheim A, Steigemann P. Lemos C, et al. Among authors: steigemann p. iScience. 2020 Sep 1;23(9):101517. doi: 10.1016/j.isci.2020.101517. eCollection 2020 Sep 25. iScience. 2020. PMID: 32927263 Free PMC article.
Computationally Empowered Workflow Identifies Novel Covalent Allosteric Binders for KRASG12C.
Mortier J, Friberg A, Badock V, Moosmayer D, Schroeder J, Steigemann P, Siegel F, Gradl S, Bauser M, Hillig RC, Briem H, Eis K, Bader B, Nguyen D, Christ CD. Mortier J, et al. Among authors: steigemann p. ChemMedChem. 2020 May 19;15(10):827-832. doi: 10.1002/cmdc.201900727. Epub 2020 Apr 1. ChemMedChem. 2020. PMID: 32237114 Free PMC article.
Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling.
Graham K, Lienau P, Bader B, Prechtl S, Naujoks J, Lesche R, Weiske J, Kuehnlenz J, Brzezinka K, Potze L, Zanconato F, Nicke B, Montebaur A, Bone W, Golfier S, Kaulfuss S, Kopitz C, Pilari S, Steuber H, Hayat S, Kamburov A, Steffen A, Schlicker A, Buchgraber P, Braeuer N, Font NA, Heinrich T, Kuhnke L, Nowak-Reppel K, Stresemann C, Steigemann P, Walter AO, Blotta S, Ocker M, Lakner A, von Nussbaum F, Mumberg D, Eis K, Piccolo S, Lange M. Graham K, et al. Among authors: steigemann p. Cell Chem Biol. 2024 Mar 19:S2451-9456(24)00087-4. doi: 10.1016/j.chembiol.2024.02.013. Online ahead of print. Cell Chem Biol. 2024. PMID: 38537632
3D high-content screening for the identification of compounds that target cells in dormant tumor spheroid regions.
Wenzel C, Riefke B, Gründemann S, Krebs A, Christian S, Prinz F, Osterland M, Golfier S, Räse S, Ansari N, Esner M, Bickle M, Pampaloni F, Mattheyer C, Stelzer EH, Parczyk K, Prechtl S, Steigemann P. Wenzel C, et al. Among authors: steigemann p. Exp Cell Res. 2014 Apr 15;323(1):131-143. doi: 10.1016/j.yexcr.2014.01.017. Epub 2014 Jan 27. Exp Cell Res. 2014. PMID: 24480576 Free article.
MISpheroID: a knowledgebase and transparency tool for minimum information in spheroid identity.
Peirsman A, Blondeel E, Ahmed T, Anckaert J, Audenaert D, Boterberg T, Buzas K, Carragher N, Castellani G, Castro F, Dangles-Marie V, Dawson J, De Tullio P, De Vlieghere E, Dedeyne S, Depypere H, Diosdi A, Dmitriev RI, Dolznig H, Fischer S, Gespach C, Goossens V, Heino J, Hendrix A, Horvath P, Kunz-Schughart LA, Maes S, Mangodt C, Mestdagh P, Michlíková S, Oliveira MJ, Pampaloni F, Piccinini F, Pinheiro C, Rahn J, Robbins SM, Siljamäki E, Steigemann P, Sys G, Takayama S, Tesei A, Tulkens J, Van Waeyenberge M, Vandesompele J, Wagemans G, Weindorfer C, Yigit N, Zablowsky N, Zanoni M, Blondeel P, De Wever O. Peirsman A, et al. Among authors: steigemann p. Nat Methods. 2021 Nov;18(11):1294-1303. doi: 10.1038/s41592-021-01291-4. Epub 2021 Nov 1. Nat Methods. 2021. PMID: 34725485 Free PMC article.
20 results