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Multiple redox switches of the SARS-CoV-2 main protease in vitro provide opportunities for drug design.
Funk LM, Poschmann G, Rabe von Pappenheim F, Chari A, Stegmann KM, Dickmanns A, Wensien M, Eulig N, Paknia E, Heyne G, Penka E, Pearson AR, Berndt C, Fritz T, Bazzi S, Uranga J, Mata RA, Dobbelstein M, Hilgenfeld R, Curth U, Tittmann K. Funk LM, et al. Among authors: stegmann km. Nat Commun. 2024 Jan 9;15(1):411. doi: 10.1038/s41467-023-44621-0. Nat Commun. 2024. PMID: 38195625 Free PMC article.
Nanobodies to multiple spike variants and inhalation of nanobody-containing aerosols neutralize SARS-CoV-2 in cell culture and hamsters.
Aksu M, Kumar P, Güttler T, Taxer W, Gregor K, Mußil B, Rymarenko O, Stegmann KM, Dickmanns A, Gerber S, Reineking W, Schulz C, Henneck T, Mohamed A, Pohlmann G, Ramazanoglu M, Mese K, Groß U, Ben-Yedidia T, Ovadia O, Fischer DW, Kamensky M, Reichman A, Baumgärtner W, von Köckritz-Blickwede M, Dobbelstein M, Görlich D. Aksu M, et al. Among authors: stegmann km. Antiviral Res. 2024 Jan;221:105778. doi: 10.1016/j.antiviral.2023.105778. Epub 2023 Dec 7. Antiviral Res. 2024. PMID: 38065245 Free article.
N4-hydroxycytidine, the active compound of Molnupiravir, promotes SARS-CoV-2 mutagenesis and escape from a neutralizing nanobody.
Zibat A, Zhang X, Dickmanns A, Stegmann KM, Dobbelstein AW, Alachram H, Soliwoda R, Salinas G, Groß U, Görlich D, Kschischo M, Wollnik B, Dobbelstein M. Zibat A, et al. Among authors: stegmann km. iScience. 2023 Aug 30;26(10):107786. doi: 10.1016/j.isci.2023.107786. eCollection 2023 Oct 20. iScience. 2023. PMID: 37731621 Free PMC article.
Tissue CD14+CD8+ T cells reprogrammed by myeloid cells and modulated by LPS.
Pallett LJ, Swadling L, Diniz M, Maini AA, Schwabenland M, Gasull AD, Davies J, Kucykowicz S, Skelton JK, Thomas N, Schmidt NM, Amin OE, Gill US, Stegmann KA, Burton AR, Stephenson E, Reynolds G, Whelan M, Sanchez J, de Maeyer R, Thakker C, Suveizdyte K, Uddin I, Ortega-Prieto AM, Grant C, Froghi F, Fusai G, Lens S, Pérez-Del-Pulgar S, Al-Akkad W, Mazza G, Noursadeghi M, Akbar A, Kennedy PTF, Davidson BR, Prinz M, Chain BM, Haniffa M, Gilroy DW, Dorner M, Bengsch B, Schurich A, Maini MK. Pallett LJ, et al. Among authors: stegmann ka. Nature. 2023 Feb;614(7947):334-342. doi: 10.1038/s41586-022-05645-6. Epub 2023 Jan 25. Nature. 2023. PMID: 36697826
43 results