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A first-in-human phase 0 clinical study of RNA interference-based spherical nucleic acids in patients with recurrent glioblastoma.
Kumthekar P, Ko CH, Paunesku T, Dixit K, Sonabend AM, Bloch O, Tate M, Schwartz M, Zuckerman L, Lezon R, Lukas RV, Jovanovic B, McCortney K, Colman H, Chen S, Lai B, Antipova O, Deng J, Li L, Tommasini-Ghelfi S, Hurley LA, Unruh D, Sharma NV, Kandpal M, Kouri FM, Davuluri RV, Brat DJ, Muzzio M, Glass M, Vijayakumar V, Heidel J, Giles FJ, Adams AK, James CD, Woloschak GE, Horbinski C, Stegh AH. Kumthekar P, et al. Among authors: stegh ah. Sci Transl Med. 2021 Mar 10;13(584):eabb3945. doi: 10.1126/scitranslmed.abb3945. Sci Transl Med. 2021. PMID: 33692132 Free PMC article. Clinical Trial.
Spherical nucleic acid nanoparticle conjugates as an RNAi-based therapy for glioblastoma.
Jensen SA, Day ES, Ko CH, Hurley LA, Luciano JP, Kouri FM, Merkel TJ, Luthi AJ, Patel PC, Cutler JI, Daniel WL, Scott AW, Rotz MW, Meade TJ, Giljohann DA, Mirkin CA, Stegh AH. Jensen SA, et al. Among authors: stegh ah. Sci Transl Med. 2013 Oct 30;5(209):209ra152. doi: 10.1126/scitranslmed.3006839. Sci Transl Med. 2013. PMID: 24174328 Free PMC article.
Spherical nucleic acids for precision medicine.
Mirkin CA, Stegh AH. Mirkin CA, et al. Among authors: stegh ah. Oncotarget. 2014 Jan 15;5(1):9-10. doi: 10.18632/oncotarget.1757. Oncotarget. 2014. PMID: 24398537 Free PMC article. No abstract available.
Bcl2L13 is a ceramide synthase inhibitor in glioblastoma.
Jensen SA, Calvert AE, Volpert G, Kouri FM, Hurley LA, Luciano JP, Wu Y, Chalastanis A, Futerman AH, Stegh AH. Jensen SA, et al. Among authors: stegh ah. Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):5682-7. doi: 10.1073/pnas.1316700111. Epub 2014 Mar 31. Proc Natl Acad Sci U S A. 2014. PMID: 24706805 Free PMC article.
NT113, a pan-ERBB inhibitor with high brain penetrance, inhibits the growth of glioblastoma xenografts with EGFR amplification.
Yoshida Y, Ozawa T, Yao TW, Shen W, Brown D, Parsa AT, Raizer JJ, Cheng SY, Stegh AH, Mazar AP, Giles FJ, Sarkaria JN, Butowski N, Nicolaides T, James CD. Yoshida Y, et al. Among authors: stegh ah. Mol Cancer Ther. 2014 Dec;13(12):2919-29. doi: 10.1158/1535-7163.MCT-14-0306. Epub 2014 Oct 13. Mol Cancer Ther. 2014. PMID: 25313012 Free PMC article.
miR-182 integrates apoptosis, growth, and differentiation programs in glioblastoma.
Kouri FM, Hurley LA, Daniel WL, Day ES, Hua Y, Hao L, Peng CY, Merkel TJ, Queisser MA, Ritner C, Zhang H, James CD, Sznajder JI, Chin L, Giljohann DA, Kessler JA, Peter ME, Mirkin CA, Stegh AH. Kouri FM, et al. Among authors: stegh ah. Genes Dev. 2015 Apr 1;29(7):732-45. doi: 10.1101/gad.257394.114. Genes Dev. 2015. PMID: 25838542 Free PMC article.
Therapeutic applications of spherical nucleic acids.
Barnaby SN, Sita TL, Petrosko SH, Stegh AH, Mirkin CA. Barnaby SN, et al. Among authors: stegh ah. Cancer Treat Res. 2015;166:23-50. doi: 10.1007/978-3-319-16555-4_2. Cancer Treat Res. 2015. PMID: 25895863 Review.
Ribozyme-Spherical Nucleic Acids.
Rouge JL, Sita TL, Hao L, Kouri FM, Briley WE, Stegh AH, Mirkin CA. Rouge JL, et al. Among authors: stegh ah. J Am Chem Soc. 2015 Aug 26;137(33):10528-10531. doi: 10.1021/jacs.5b07104. Epub 2015 Aug 14. J Am Chem Soc. 2015. PMID: 26271335 Free PMC article.
39 results