Steffan JS - Search Results

1

Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease.

McQuade A, Kang YJ, Hasselmann J, Jairaman A, Sotelo A, Coburn M, Shabestari SK, Chadarevian JP, Fote G, Tu CH, Danhash E, Silva J, Martinez E, Cotman C, Prieto GA, Thompson LM, Steffan JS, Smith I, Davtyan H, Cahalan M, Cho H, Blurton-Jones M. McQuade A, et al. Among authors: steffan js. Nat Commun. 2020 Oct 23;11(1):5370. doi: 10.1038/s41467-020-19227-5. Nat Commun. 2020. PMID: 33097708 Free PMC article.

2

Gene sequence and primary structure of mitochondrial malate dehydrogenase from Saccharomyces cerevisiae.

Thompson LM, Sutherland P, Steffan JS, McAlister-Henn L. Thompson LM, et al. Among authors: steffan js. Biochemistry. 1988 Nov 1;27(22):8393-400. doi: 10.1021/bi00422a015. Biochemistry. 1988. PMID: 3072021

3

Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila.

Steffan JS, Bodai L, Pallos J, Poelman M, McCampbell A, Apostol BL, Kazantsev A, Schmidt E, Zhu YZ, Greenwald M, Kurokawa R, Housman DE, Jackson GR, Marsh JL, Thompson LM. Steffan JS, et al. Nature. 2001 Oct 18;413(6857):739-43. doi: 10.1038/35099568. Nature. 2001. PMID: 11607033

4

Targeting aggregation in the development of therapeutics for the treatment of Huntington's disease and other polyglutamine repeat diseases.

Steffan JS, Thompson LM. Steffan JS, et al. Expert Opin Ther Targets. 2003 Apr;7(2):201-13. doi: 10.1517/14728222.7.2.201. Expert Opin Ther Targets. 2003. PMID: 12667098 Review.

5

Normal-repeat-length polyglutamine peptides accelerate aggregation nucleation and cytotoxicity of expanded polyglutamine proteins.

Slepko N, Bhattacharyya AM, Jackson GR, Steffan JS, Marsh JL, Thompson LM, Wetzel R. Slepko N, et al. Among authors: steffan js. Proc Natl Acad Sci U S A. 2006 Sep 26;103(39):14367-72. doi: 10.1073/pnas.0602348103. Epub 2006 Sep 15. Proc Natl Acad Sci U S A. 2006. PMID: 16980414 Free PMC article.

6

Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington's disease.

Pallos J, Bodai L, Lukacsovich T, Purcell JM, Steffan JS, Thompson LM, Marsh JL. Pallos J, et al. Among authors: steffan js. Hum Mol Genet. 2008 Dec 1;17(23):3767-75. doi: 10.1093/hmg/ddn273. Epub 2008 Sep 1. Hum Mol Genet. 2008. PMID: 18762557 Free PMC article.

7

Nicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau.

Green KN, Steffan JS, Martinez-Coria H, Sun X, Schreiber SS, Thompson LM, LaFerla FM. Green KN, et al. Among authors: steffan js. J Neurosci. 2008 Nov 5;28(45):11500-10. doi: 10.1523/JNEUROSCI.3203-08.2008. J Neurosci. 2008. PMID: 18987186 Free PMC article.

8

Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice.

Gu X, Greiner ER, Mishra R, Kodali R, Osmand A, Finkbeiner S, Steffan JS, Thompson LM, Wetzel R, Yang XW. Gu X, et al. Among authors: steffan js. Neuron. 2009 Dec 24;64(6):828-40. doi: 10.1016/j.neuron.2009.11.020. Neuron. 2009. PMID: 20064390 Free PMC article.

9

Potential function for the Huntingtin protein as a scaffold for selective autophagy.

Ochaba J, Lukacsovich T, Csikos G, Zheng S, Margulis J, Salazar L, Mao K, Lau AL, Yeung SY, Humbert S, Saudou F, Klionsky DJ, Finkbeiner S, Zeitlin SO, Marsh JL, Housman DE, Thompson LM, Steffan JS. Ochaba J, et al. Among authors: steffan js. Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16889-94. doi: 10.1073/pnas.1420103111. Epub 2014 Nov 10. Proc Natl Acad Sci U S A. 2014. PMID: 25385587 Free PMC article.

10

PIAS1 Regulates Mutant Huntingtin Accumulation and Huntington's Disease-Associated Phenotypes In Vivo.

Ochaba J, Monteys AM, O'Rourke JG, Reidling JC, Steffan JS, Davidson BL, Thompson LM. Ochaba J, et al. Among authors: steffan js. Neuron. 2016 May 4;90(3):507-20. doi: 10.1016/j.neuron.2016.03.016. Epub 2016 Apr 14. Neuron. 2016. PMID: 27146268 Free PMC article.

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