Stefano JE - Search Results

1

Site-specific antibody-drug conjugation through glycoengineering.

Zhou Q, Stefano JE, Manning C, Kyazike J, Chen B, Gianolio DA, Park A, Busch M, Bird J, Zheng X, Simonds-Mannes H, Kim J, Gregory RC, Miller RJ, Brondyk WH, Dhal PK, Pan CQ. Zhou Q, et al. Among authors: stefano je. Bioconjug Chem. 2014 Mar 19;25(3):510-20. doi: 10.1021/bc400505q. Epub 2014 Feb 28. Bioconjug Chem. 2014. PMID: 24533768

2

Strategies for Neoglycan conjugation to human acid α-glucosidase.

Zhou Q, Stefano JE, Harrahy J, Finn P, Avila L, Kyazike J, Wei R, Van Patten SM, Gotschall R, Zheng X, Zhu Y, Edmunds T, Pan CQ. Zhou Q, et al. Among authors: stefano je. Bioconjug Chem. 2011 Apr 20;22(4):741-51. doi: 10.1021/bc1005416. Epub 2011 Mar 18. Bioconjug Chem. 2011. PMID: 21417264

3

High-affinity VEGF antagonists by oligomerization of a minimal sequence VEGF-binding domain.

Stefano JE, Bird J, Kyazike J, Cheng AW, Boudanova E, Dwyer M, Hou L, Qiu H, Matthews G, O'Callaghan M, Pan CQ. Stefano JE, et al. Bioconjug Chem. 2012 Dec 19;23(12):2354-64. doi: 10.1021/bc300301m. Epub 2012 Dec 10. Bioconjug Chem. 2012. PMID: 23176598

4

Micro- and mid-scale maleimide-based conjugation of cytotoxic drugs to antibody hinge region thiols for tumor targeting.

Stefano JE, Busch M, Hou L, Park A, Gianolio DA. Stefano JE, et al. Methods Mol Biol. 2013;1045:145-71. doi: 10.1007/978-1-62703-541-5_9. Methods Mol Biol. 2013. PMID: 23913146

5

Convergent synthesis of hydrophilic monomethyl dolastatin 10 based drug linkers for antibody-drug conjugation.

Yang K, Chen B, Gianolio DA, Stefano JE, Busch M, Manning C, Alving K, Gregory RC, Brondyk WH, Miller RJ, Dhal PK. Yang K, et al. Among authors: stefano je. Org Biomol Chem. 2019 Sep 21;17(35):8115-8124. doi: 10.1039/c9ob01639b. Epub 2019 Aug 28. Org Biomol Chem. 2019. PMID: 31460552

6

Carbohydrate-mediated polyethylene glycol conjugation of TSH improves its pharmacological properties.

Park A, Honey DM, Hou L, Bird JJ, Zarazinski C, Searles M, Braithwaite C, Kingsbury JS, Kyazike J, Culm-Merdek K, Greene B, Stefano JE, Qiu H, McPherson JM, Pan CQ. Park A, et al. Among authors: stefano je. Endocrinology. 2013 Mar;154(3):1373-83. doi: 10.1210/en.2012-2010. Epub 2013 Feb 6. Endocrinology. 2013. PMID: 23389953

7

Design, Synthesis, and in vitro Evaluation of Multivalent Drug Linkers for High-Drug-Load Antibody-Drug Conjugates.

Chen B, Gianolio DA, Stefano JE, Manning CM, Gregory RC, Busch MM, Brondyk WH, Miller RJ, Dhal PK. Chen B, et al. Among authors: stefano je. ChemMedChem. 2018 Apr 23;13(8):790-794. doi: 10.1002/cmdc.201700722. Epub 2018 Mar 8. ChemMedChem. 2018. PMID: 29517131

8

Targeting HER2-positive cancer with dolastatin 15 derivatives conjugated to trastuzumab, novel antibody-drug conjugates.

Gianolio DA, Rouleau C, Bauta WE, Lovett D, Cantrell WR Jr, Recio A 3rd, Wolstenholme-Hogg P, Busch M, Pan P, Stefano JE, Kramer HM, Goebel J, Krumbholz RD, Roth S, Schmid SM, Teicher BA. Gianolio DA, et al. Among authors: stefano je. Cancer Chemother Pharmacol. 2012 Sep;70(3):439-49. doi: 10.1007/s00280-012-1925-8. Epub 2012 Jul 22. Cancer Chemother Pharmacol. 2012. PMID: 22821053

9

In vitro and in vivo evaluation of a non-carbohydrate targeting platform for lysosomal proteins.

Stefano JE, Hou L, Honey D, Kyazike J, Park A, Zhou Q, Pan CQ, Edmunds T. Stefano JE, et al. J Control Release. 2009 Apr 17;135(2):113-8. doi: 10.1016/j.jconrel.2008.12.006. Epub 2008 Dec 24. J Control Release. 2009. PMID: 19146893

10

A highly potent CD73 biparatopic antibody blocks organization of the enzyme active site through dual mechanisms.

Stefano JE, Lord DM, Zhou Y, Jaworski J, Hopke J, Travaline T, Zhang N, Wong K, Lennon A, He T, Bric-Furlong E, Cherrie C, Magnay T, Remy E, Brondyk W, Qiu H, Radošević K. Stefano JE, et al. J Biol Chem. 2020 Dec 25;295(52):18379-18389. doi: 10.1074/jbc.RA120.012395. Epub 2020 Oct 29. J Biol Chem. 2020. PMID: 33122192 Free PMC article.

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