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Mitohormesis and metabolic health: The interplay between ROS, cAMP and sirtuins.
Palmeira CM, Teodoro JS, Amorim JA, Steegborn C, Sinclair DA, Rolo AP. Palmeira CM, et al. Among authors: steegborn c. Free Radic Biol Med. 2019 Sep;141:483-491. doi: 10.1016/j.freeradbiomed.2019.07.017. Epub 2019 Jul 24. Free Radic Biol Med. 2019. PMID: 31349039 Free PMC article. Review.
On-demand male contraception via acute inhibition of soluble adenylyl cyclase.
Balbach M, Rossetti T, Ferreira J, Ghanem L, Ritagliati C, Myers RW, Huggins DJ, Steegborn C, Miranda IC, Meinke PT, Buck J, Levin LR. Balbach M, et al. Among authors: steegborn c. Nat Commun. 2023 Feb 14;14(1):637. doi: 10.1038/s41467-023-36119-6. Nat Commun. 2023. PMID: 36788210 Free PMC article.
Dietary restriction: standing up for sirtuins.
Baur JA, Chen D, Chini EN, Chua K, Cohen HY, de Cabo R, Deng C, Dimmeler S, Gius D, Guarente LP, Helfand SL, Imai S, Itoh H, Kadowaki T, Koya D, Leeuwenburgh C, McBurney M, Nabeshima Y, Neri C, Oberdoerffer P, Pestell RG, Rogina B, Sadoshima J, Sartorelli V, Serrano M, Sinclair DA, Steegborn C, Tatar M, Tissenbaum HA, Tong Q, Tsubota K, Vaquero A, Verdin E. Baur JA, et al. Among authors: steegborn c. Science. 2010 Aug 27;329(5995):1012-3; author reply 1013-4. doi: 10.1126/science.329.5995.1012. Science. 2010. PMID: 20798296 Free PMC article. No abstract available.
Selective Sirt2 inhibition by ligand-induced rearrangement of the active site.
Rumpf T, Schiedel M, Karaman B, Roessler C, North BJ, Lehotzky A, Oláh J, Ladwein KI, Schmidtkunz K, Gajer M, Pannek M, Steegborn C, Sinclair DA, Gerhardt S, Ovádi J, Schutkowski M, Sippl W, Einsle O, Jung M. Rumpf T, et al. Among authors: steegborn c. Nat Commun. 2015 Feb 12;6:6263. doi: 10.1038/ncomms7263. Nat Commun. 2015. PMID: 25672491 Free PMC article.
Potent and Specific Activators for Mitochondrial Sirtuins Sirt3 and Sirt5.
Suenkel B, Valente S, Zwergel C, Weiss S, Di Bello E, Fioravanti R, Aventaggiato M, Amorim JA, Garg N, Kumar S, Lombard DB, Hu T, Singh PK, Tafani M, Palmeira CM, Sinclair D, Mai A, Steegborn C. Suenkel B, et al. Among authors: steegborn c. J Med Chem. 2022 Oct 27;65(20):14015-14031. doi: 10.1021/acs.jmedchem.2c01215. Epub 2022 Oct 13. J Med Chem. 2022. PMID: 36228194 Free PMC article.
133 results