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Novel Quinoline Compounds Active in Cancer Cells through Coupled DNA Methyltransferase Inhibition and Degradation.
Zwergel C, Fioravanti R, Stazi G, Sarno F, Battistelli C, Romanelli A, Nebbioso A, Mendes E, Paulo A, Strippoli R, Tripodi M, Pechalrieu D, Arimondo PB, De Luca T, Del Bufalo D, Trisciuoglio D, Altucci L, Valente S, Mai A. Zwergel C, et al. Among authors: stazi g. Cancers (Basel). 2020 Feb 14;12(2):447. doi: 10.3390/cancers12020447. Cancers (Basel). 2020. PMID: 32075099 Free PMC article.
Discovery of a Novel Inhibitor of Histone Lysine-Specific Demethylase 1A (KDM1A/LSD1) as Orally Active Antitumor Agent.
Vianello P, Botrugno OA, Cappa A, Dal Zuffo R, Dessanti P, Mai A, Marrocco B, Mattevi A, Meroni G, Minucci S, Stazi G, Thaler F, Trifiró P, Valente S, Villa M, Varasi M, Mercurio C. Vianello P, et al. Among authors: stazi g. J Med Chem. 2016 Feb 25;59(4):1501-17. doi: 10.1021/acs.jmedchem.5b01209. Epub 2016 Jan 7. J Med Chem. 2016. PMID: 26702542
LSD1 inhibitors: a patent review (2010-2015).
Stazi G, Zwergel C, Valente S, Mai A. Stazi G, et al. Expert Opin Ther Pat. 2016 May;26(5):565-80. doi: 10.1517/13543776.2016.1165209. Epub 2016 Mar 28. Expert Opin Ther Pat. 2016. PMID: 27019002 Review.
EZH2 inhibitors: a patent review (2014-2016).
Stazi G, Zwergel C, Mai A, Valente S. Stazi G, et al. Expert Opin Ther Pat. 2017 Jul;27(7):797-813. doi: 10.1080/13543776.2017.1316976. Epub 2017 Apr 20. Expert Opin Ther Pat. 2017. PMID: 28394193 Review.
Novel coumarin- and quinolinone-based polycycles as cell division cycle 25-A and -C phosphatases inhibitors induce proliferation arrest and apoptosis in cancer cells.
Zwergel C, Czepukojc B, Evain-Bana E, Xu Z, Stazi G, Mori M, Patsilinakos A, Mai A, Botta B, Ragno R, Bagrel D, Kirsch G, Meiser P, Jacob C, Montenarh M, Valente S. Zwergel C, et al. Among authors: stazi g. Eur J Med Chem. 2017 Jul 7;134:316-333. doi: 10.1016/j.ejmech.2017.04.012. Epub 2017 Apr 10. Eur J Med Chem. 2017. PMID: 28431339
The histone methyltransferase EZH2 as a druggable target in SHH medulloblastoma cancer stem cells.
Miele E, Valente S, Alfano V, Silvano M, Mellini P, Borovika D, Marrocco B, Po A, Besharat ZM, Catanzaro G, Battaglia G, Abballe L, Zwergel C, Stazi G, Milite C, Castellano S, Tafani M, Trapencieris P, Mai A, Ferretti E. Miele E, et al. Among authors: stazi g. Oncotarget. 2017 Aug 2;8(40):68557-68570. doi: 10.18632/oncotarget.19782. eCollection 2017 Sep 15. Oncotarget. 2017. PMID: 28978137 Free PMC article.
Pyrazole-based inhibitors of enhancer of zeste homologue 2 induce apoptosis and autophagy in cancer cells.
Mellini P, Marrocco B, Borovika D, Polletta L, Carnevale I, Saladini S, Stazi G, Zwergel C, Trapencieris P, Ferretti E, Tafani M, Valente S, Mai A. Mellini P, et al. Among authors: stazi g. Philos Trans R Soc Lond B Biol Sci. 2018 Jun 5;373(1748):20170150. doi: 10.1098/rstb.2017.0150. Philos Trans R Soc Lond B Biol Sci. 2018. PMID: 29685965 Free PMC article.
Trends of LSD1 inhibitors in viral infections.
Zwergel C, Stazi G, Mai A, Valente S. Zwergel C, et al. Among authors: stazi g. Future Med Chem. 2018 May 1;10(10):1133-1136. doi: 10.4155/fmc-2018-0065. Epub 2018 May 22. Future Med Chem. 2018. PMID: 29787289 Free article. No abstract available.
A Quinoline-Based DNA Methyltransferase Inhibitor as a Possible Adjuvant in Osteosarcoma Therapy.
Manara MC, Valente S, Cristalli C, Nicoletti G, Landuzzi L, Zwergel C, Mazzone R, Stazi G, Arimondo PB, Pasello M, Guerzoni C, Picci P, Nanni P, Lollini PL, Mai A, Scotlandi K. Manara MC, et al. Among authors: stazi g. Mol Cancer Ther. 2018 Sep;17(9):1881-1892. doi: 10.1158/1535-7163.MCT-17-0818. Epub 2018 Jun 29. Mol Cancer Ther. 2018. PMID: 29959201
Correction to 'Pyrazole-based inhibitors of enhancer of zeste homologue 2 induce apoptosis and autophagy in cancer cells'.
Mellini P, Marrocco B, Borovika D, Polletta L, Carnevale I, Saladini S, Stazi G, Zwergel C, Trapencieris P, Ferretti E, Tafani M, Valente S, Mai A. Mellini P, et al. Among authors: stazi g. Philos Trans R Soc Lond B Biol Sci. 2018 Sep 19;373(1755):20180305. doi: 10.1098/rstb.2018.0305. Philos Trans R Soc Lond B Biol Sci. 2018. PMID: 30061471 Free PMC article. No abstract available.
55 results