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Noncanonical scaffolding of Gαi and β-arrestin by G protein-coupled receptors.
Smith JS, Pack TF, Inoue A, Lee C, Zheng K, Choi I, Eiger DS, Warman A, Xiong X, Ma Z, Viswanathan G, Levitan IM, Rochelle LK, Staus DP, Snyder JC, Kahsai AW, Caron MG, Rajagopal S. Smith JS, et al. Among authors: staus dp. Science. 2021 Mar 12;371(6534):eaay1833. doi: 10.1126/science.aay1833. Epub 2021 Jan 21. Science. 2021. PMID: 33479120 Free PMC article.
Mechanism of β2AR regulation by an intracellular positive allosteric modulator.
Liu X, Masoudi A, Kahsai AW, Huang LY, Pani B, Staus DP, Shim PJ, Hirata K, Simhal RK, Schwalb AM, Rambarat PK, Ahn S, Lefkowitz RJ, Kobilka B. Liu X, et al. Among authors: staus dp. Science. 2019 Jun 28;364(6447):1283-1287. doi: 10.1126/science.aaw8981. Epub 2019 Jun 27. Science. 2019. PMID: 31249059 Free PMC article.
Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor.
Kahsai AW, Wisler JW, Lee J, Ahn S, Cahill Iii TJ, Dennison SM, Staus DP, Thomsen AR, Anasti KM, Pani B, Wingler LM, Desai H, Bompiani KM, Strachan RT, Qin X, Alam SM, Sullenger BA, Lefkowitz RJ. Kahsai AW, et al. Among authors: staus dp. Nat Chem Biol. 2016 Sep;12(9):709-16. doi: 10.1038/nchembio.2126. Epub 2016 Jul 11. Nat Chem Biol. 2016. PMID: 27398998 Free PMC article.
Small-Molecule Positive Allosteric Modulators of the β2-Adrenoceptor Isolated from DNA-Encoded Libraries.
Ahn S, Pani B, Kahsai AW, Olsen EK, Husemoen G, Vestergaard M, Jin L, Zhao S, Wingler LM, Rambarat PK, Simhal RK, Xu TT, Sun LD, Shim PJ, Staus DP, Huang LY, Franch T, Chen X, Lefkowitz RJ. Ahn S, et al. Among authors: staus dp. Mol Pharmacol. 2018 Aug;94(2):850-861. doi: 10.1124/mol.118.111948. Epub 2018 May 16. Mol Pharmacol. 2018. PMID: 29769246 Free PMC article.
Allosteric "beta-blocker" isolated from a DNA-encoded small molecule library.
Ahn S, Kahsai AW, Pani B, Wang QT, Zhao S, Wall AL, Strachan RT, Staus DP, Wingler LM, Sun LD, Sinnaeve J, Choi M, Cho T, Xu TT, Hansen GM, Burnett MB, Lamerdin JE, Bassoni DL, Gavino BJ, Husemoen G, Olsen EK, Franch T, Costanzi S, Chen X, Lefkowitz RJ. Ahn S, et al. Among authors: staus dp. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1708-1713. doi: 10.1073/pnas.1620645114. Epub 2017 Jan 27. Proc Natl Acad Sci U S A. 2017. PMID: 28130548 Free PMC article.
29 results