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Arylsulfonamide pyrimidines as VLA-4 antagonists.
Xu YZ, Konradi AW, Bard F, Dappen M, Dofiles L, Dreyer M, Gallager I, Garrido C, Krimm M, Liao Z, Messersmith E, Mutter L, Pleiss MA, Samant B, Semko CM, Smith J, Stappenbeck F, Stupi B, Vandervert C, Welch B, Wipke B, Yednock T. Xu YZ, et al. Among authors: stappenbeck f. Bioorg Med Chem Lett. 2013 May 15;23(10):3070-4. doi: 10.1016/j.bmcl.2013.03.010. Epub 2013 Mar 15. Bioorg Med Chem Lett. 2013. PMID: 23562062
Fragment-based discovery of JAK-2 inhibitors.
Antonysamy S, Hirst G, Park F, Sprengeler P, Stappenbeck F, Steensma R, Wilson M, Wong M. Antonysamy S, et al. Among authors: stappenbeck f. Bioorg Med Chem Lett. 2009 Jan 1;19(1):279-82. doi: 10.1016/j.bmcl.2008.08.064. Epub 2008 Aug 22. Bioorg Med Chem Lett. 2009. PMID: 19019674
Novel oxysterols activate the Hedgehog pathway and induce osteogenesis.
Stappenbeck F, Xiao W, Epperson M, Riley M, Priest A, Huang D, Nguyen K, Jung ME, Thies RS, Farouz F. Stappenbeck F, et al. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5893-7. doi: 10.1016/j.bmcl.2012.07.073. Epub 2012 Jul 27. Bioorg Med Chem Lett. 2012. PMID: 22901899
A novel osteogenic oxysterol compound for therapeutic development to promote bone growth: activation of hedgehog signaling and osteogenesis through smoothened binding.
Montgomery SR, Nargizyan T, Meliton V, Nachtergaele S, Rohatgi R, Stappenbeck F, Jung ME, Johnson JS, Aghdasi B, Tian H, Weintraub G, Inoue H, Atti E, Tetradis S, Pereira RC, Hokugo A, Alobaidaan R, Tan Y, Hahn TJ, Wang JC, Parhami F. Montgomery SR, et al. Among authors: stappenbeck f. J Bone Miner Res. 2014 Aug;29(8):1872-85. doi: 10.1002/jbmr.2213. J Bone Miner Res. 2014. PMID: 24591126 Free PMC article.
17 results