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Structure-based design of aliskiren, a novel orally effective renin inhibitor.
Wood JM, Maibaum J, Rahuel J, Grütter MG, Cohen NC, Rasetti V, Rüger H, Göschke R, Stutz S, Fuhrer W, Schilling W, Rigollier P, Yamaguchi Y, Cumin F, Baum HP, Schnell CR, Herold P, Mah R, Jensen C, O'Brien E, Stanton A, Bedigian MP. Wood JM, et al. Among authors: stanton a. Biochem Biophys Res Commun. 2003 Sep 5;308(4):698-705. doi: 10.1016/s0006-291x(03)01451-7. Biochem Biophys Res Commun. 2003. PMID: 12927775
Aliskiren reduces blood pressure and suppresses plasma renin activity in combination with a thiazide diuretic, an angiotensin-converting enzyme inhibitor, or an angiotensin receptor blocker.
O'Brien E, Barton J, Nussberger J, Mulcahy D, Jensen C, Dicker P, Stanton A. O'Brien E, et al. Among authors: stanton a. Hypertension. 2007 Feb;49(2):276-84. doi: 10.1161/01.HYP.0000253780.36691.4f. Epub 2006 Dec 11. Hypertension. 2007. PMID: 17159081 Clinical Trial.
Serum amyloid A, C-reactive protein, and retinal microvascular changes in hypertensive diabetic and nondiabetic individuals: an Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) substudy.
Stettler C, Witt N, Tapp RJ, Thom S, Allemann S, Tillin T, Stanton A, O'Brien E, Poulter N, Gallimore JR, Hughes AD, Chaturvedi N. Stettler C, et al. Among authors: stanton a. Diabetes Care. 2009 Jun;32(6):1098-100. doi: 10.2337/dc08-2137. Epub 2009 Feb 24. Diabetes Care. 2009. PMID: 19244088 Free PMC article.
Ambulatory arterial stiffness index: determinants and outcome.
Li Y, Dolan E, Wang JG, Thijs L, Zhu DL, Staessen JA, O'Brien E, Stanton A. Li Y, et al. Among authors: stanton a. Blood Press Monit. 2006 Apr;11(2):107-10. doi: 10.1097/01.mbp.0000189791.90488.a1. Blood Press Monit. 2006. PMID: 16534414 Free article.
Ambulatory arterial stiffness index: rationale and methodology.
Dolan E, Li Y, Thijs L, McCormack P, Staessen JA, O'Brien E, Stanton A. Dolan E, et al. Among authors: stanton a. Blood Press Monit. 2006 Apr;11(2):103-5. doi: 10.1097/01.mbp.0000200478.19046.dd. Blood Press Monit. 2006. PMID: 16534413 Free article.
Potential of renin inhibition in cardiovascular disease.
Stanton A. Stanton A. J Renin Angiotensin Aldosterone Syst. 2003 Mar;4(1):6-10. doi: 10.3317/jraas.2003.008. J Renin Angiotensin Aldosterone Syst. 2003. PMID: 12692747 Free article. Review.
766 results