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It takes two (Las1 HEPN endoribonuclease domains) to cut RNA correctly.
Pillon MC, Goslen KH, Gordon J, Wells ML, Williams JG, Stanley RE. Pillon MC, et al. Among authors: stanley re. J Biol Chem. 2020 May 1;295(18):5857-5870. doi: 10.1074/jbc.RA119.011193. Epub 2020 Mar 27. J Biol Chem. 2020. PMID: 32220933 Free PMC article.
Cryo-EM Structures of the SARS-CoV-2 Endoribonuclease Nsp15.
Pillon MC, Frazier MN, Dillard LB, Williams JG, Kocaman S, Krahn JM, Perera L, Hayne CK, Gordon J, Stewart ZD, Sobhany M, Deterding LJ, Hsu AL, Dandey VP, Borgnia MJ, Stanley RE. Pillon MC, et al. Among authors: stanley re. bioRxiv [Preprint]. 2020 Aug 11:2020.08.11.244863. doi: 10.1101/2020.08.11.244863. bioRxiv. 2020. PMID: 32803198 Free PMC article. Updated. Preprint.
Cryo-EM structures of the SARS-CoV-2 endoribonuclease Nsp15 reveal insight into nuclease specificity and dynamics.
Pillon MC, Frazier MN, Dillard LB, Williams JG, Kocaman S, Krahn JM, Perera L, Hayne CK, Gordon J, Stewart ZD, Sobhany M, Deterding LJ, Hsu AL, Dandey VP, Borgnia MJ, Stanley RE. Pillon MC, et al. Among authors: stanley re. Nat Commun. 2021 Jan 27;12(1):636. doi: 10.1038/s41467-020-20608-z. Nat Commun. 2021. PMID: 33504779 Free PMC article.
81 results