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Genetic coding variant in complement factor B (CFB) is associated with increased risk for perianal Crohn's disease and leads to impaired CFB cleavage and phagocytosis.
Akhlaghpour M, Haritunians T, More SK, Thomas LS, Stamps DT, Dube S, Li D, Yang S, Landers CJ, Mengesha E, Hamade H, Murali R, Potdar AA, Wolf AJ, Botwin GJ, Khrom M; International IBD Genetics Consortium; Ananthakrishnan AN, Faubion WA, Jabri B, Lira SA, Newberry RD, Sandler RS, Sartor RB, Xavier RJ, Brant SR, Cho JH, Duerr RH, Lazarev MG, Rioux JD, Schumm LP, Silverberg MS, Zaghiyan K, Fleshner P, Melmed GY, Vasiliauskas EA, Ha C, Rabizadeh S, Syal G, Bonthala NN, Ziring DA, Targan SR, Long MD, McGovern DPB, Michelsen KS. Akhlaghpour M, et al. Among authors: stamps dt. Gut. 2023 Nov;72(11):2068-2080. doi: 10.1136/gutjnl-2023-329689. Epub 2023 Apr 20. Gut. 2023. PMID: 37080587 Free article.
BATF3 Protects Against Metabolic Syndrome and Maintains Intestinal Epithelial Homeostasis.
Hamade H, Stamps JT, Stamps DT, More SK, Thomas LS, Blackwood AY, Lahcene NL, Castanon SL, Salumbides BC, Shimodaira Y, Goodridge HS, Targan SR, Michelsen KS. Hamade H, et al. Among authors: stamps dt. Front Immunol. 2022 Jun 22;13:841065. doi: 10.3389/fimmu.2022.841065. eCollection 2022. Front Immunol. 2022. PMID: 35812447 Free PMC article.
DR3 Regulates Intestinal Epithelial Homeostasis and Regeneration After Intestinal Barrier Injury.
Shimodaira Y, More SK, Hamade H, Blackwood AY, Abraham JP, Thomas LS, Miller JH, Stamps DT, Castanon SL, Jacob N, Ha CWY, Devkota S, Shih DQ, Targan SR, Michelsen KS. Shimodaira Y, et al. Among authors: stamps dt. Cell Mol Gastroenterol Hepatol. 2023;16(1):83-105. doi: 10.1016/j.jcmgh.2023.03.008. Epub 2023 Apr 1. Cell Mol Gastroenterol Hepatol. 2023. PMID: 37011811 Free PMC article.
Direct signaling of TL1A-DR3 on fibroblasts induces intestinal fibrosis in vivo.
Jacob N, Kumagai K, Abraham JP, Shimodaira Y, Ye Y, Luu J, Blackwood AY, Castanon SL, Stamps DT, Thomas LS, Gonsky R, Shih DQ, Michelsen KS, Targan SR. Jacob N, et al. Among authors: stamps dt. Sci Rep. 2020 Oct 23;10(1):18189. doi: 10.1038/s41598-020-75168-5. Sci Rep. 2020. PMID: 33097818 Free PMC article.