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A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells.
Mahoney M, Damalanka VC, Tartell MA, Chung DH, Lourenço AL, Pwee D, Mayer Bridwell AE, Hoffmann M, Voss J, Karmakar P, Azouz NP, Klingler AM, Rothlauf PW, Thompson CE, Lee M, Klampfer L, Stallings CL, Rothenberg ME, Pöhlmann S, Whelan SPJ, O'Donoghue AJ, Craik CS, Janetka JW. Mahoney M, et al. Among authors: stallings cl. Proc Natl Acad Sci U S A. 2021 Oct 26;118(43):e2108728118. doi: 10.1073/pnas.2108728118. Proc Natl Acad Sci U S A. 2021. PMID: 34635581 Free PMC article.
A promising bioconjugate vaccine against hypervirulent Klebsiella pneumoniae.
Feldman MF, Mayer Bridwell AE, Scott NE, Vinogradov E, McKee SR, Chavez SM, Twentyman J, Stallings CL, Rosen DA, Harding CM. Feldman MF, et al. Among authors: stallings cl. Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18655-18663. doi: 10.1073/pnas.1907833116. Epub 2019 Aug 27. Proc Natl Acad Sci U S A. 2019. PMID: 31455739 Free PMC article.
Perspectives and Advances in the Understanding of Tuberculosis.
Kinsella RL, Zhu DX, Harrison GA, Mayer Bridwell AE, Prusa J, Chavez SM, Stallings CL. Kinsella RL, et al. Among authors: stallings cl. Annu Rev Pathol. 2021 Jan 24;16:377-408. doi: 10.1146/annurev-pathol-042120-032916. Annu Rev Pathol. 2021. PMID: 33497258 Review.
Chemical disarming of isoniazid resistance in Mycobacterium tuberculosis.
Flentie K, Harrison GA, Tükenmez H, Livny J, Good JAD, Sarkar S, Zhu DX, Kinsella RL, Weiss LA, Solomon SD, Schene ME, Hansen MR, Cairns AG, Kulén M, Wixe T, Lindgren AEG, Chorell E, Bengtsson C, Krishnan KS, Hultgren SJ, Larsson C, Almqvist F, Stallings CL. Flentie K, et al. Among authors: stallings cl. Proc Natl Acad Sci U S A. 2019 May 21;116(21):10510-10517. doi: 10.1073/pnas.1818009116. Epub 2019 May 6. Proc Natl Acad Sci U S A. 2019. PMID: 31061116 Free PMC article.
UFMylation inhibits the proinflammatory capacity of interferon-γ-activated macrophages.
Balce DR, Wang YT, McAllaster MR, Dunlap BF, Orvedahl A, Hykes BL Jr, Droit L, Handley SA, Wilen CB, Doench JG, Orchard RC, Stallings CL, Virgin HW. Balce DR, et al. Among authors: stallings cl. Proc Natl Acad Sci U S A. 2021 Jan 5;118(1):e2011763118. doi: 10.1073/pnas.2011763118. Proc Natl Acad Sci U S A. 2021. PMID: 33372156 Free PMC article.
Design, Synthesis, and Evaluation of Novel Δ2-Thiazolino 2-Pyridone Derivatives That Potentiate Isoniazid Activity in an Isoniazid-Resistant Mycobacterium tuberculosis Mutant.
Sarkar S, Mayer Bridwell AE, Good JAD, Wang ER, McKee SR, Valenta J, Harrison GA, Flentie KN, Henry FL, Wixe T, Demirel P, Vagolu SK, Chatagnon J, Machelart A, Brodin P, Tønjum T, Stallings CL, Almqvist F. Sarkar S, et al. Among authors: stallings cl. J Med Chem. 2023 Aug 24;66(16):11056-11077. doi: 10.1021/acs.jmedchem.3c00358. Epub 2023 Jul 24. J Med Chem. 2023. PMID: 37485869 Free PMC article.
Structure and function of CarD, an essential mycobacterial transcription factor.
Srivastava DB, Leon K, Osmundson J, Garner AL, Weiss LA, Westblade LF, Glickman MS, Landick R, Darst SA, Stallings CL, Campbell EA. Srivastava DB, et al. Among authors: stallings cl. Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12619-24. doi: 10.1073/pnas.1308270110. Epub 2013 Jul 15. Proc Natl Acad Sci U S A. 2013. PMID: 23858468 Free PMC article.
72 results