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Receptor tyrosine kinases regulate signal transduction through a liquid-liquid phase separated state.
Mol Cell. 2022 Mar 17;82(6):1089-1106.e12. doi: 10.1016/j.molcel.2022.02.005. Epub 2022 Feb 28.
Mol Cell. 2022.
PMID: 35231400
Free PMC article.
Targeting the Shc-EGFR interaction with indomethacin inhibits MAP kinase pathway signalling.
Lin CC, Suen KM, Stainthorp A, Wieteska L, Biggs GS, Leitão A, Montanari CA, Ladbury JE.
Lin CC, et al. Among authors: stainthorp a.
Cancer Lett. 2019 Aug 10;457:86-97. doi: 10.1016/j.canlet.2019.05.008. Epub 2019 May 14.
Cancer Lett. 2019.
PMID: 31100409
Free PMC article.
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The Grb2 splice variant, Grb3-3, is a negative regulator of RAS activation.
Seiler C, Stainthorp AK, Ketchen S, Jones CM, Marks K, Quirke P, Ladbury JE.
Seiler C, et al. Among authors: stainthorp ak.
Commun Biol. 2022 Sep 28;5(1):1029. doi: 10.1038/s42003-022-03985-7.
Commun Biol. 2022.
PMID: 36171279
Free PMC article.
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Regulation of microRNA expression by the adaptor protein GRB2.
Stainthorp AK, Lin CC, Wang D, Medhi R, Ahmed Z, Suen KM, Miska EA, Whitehouse A, Ladbury JE.
Stainthorp AK, et al.
Sci Rep. 2023 Jun 16;13(1):9784. doi: 10.1038/s41598-023-36996-3.
Sci Rep. 2023.
PMID: 37328606
Free PMC article.
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Rab27a co-ordinates actin-dependent transport by controlling organelle-associated motors and track assembly proteins.
Alzahofi N, Welz T, Robinson CL, Page EL, Briggs DA, Stainthorp AK, Reekes J, Elbe DA, Straub F, Kallemeijn WW, Tate EW, Goff PS, Sviderskaya EV, Cantero M, Montoliu L, Nedelec F, Miles AK, Bailly M, Kerkhoff E, Hume AN.
Alzahofi N, et al. Among authors: stainthorp ak.
Nat Commun. 2020 Jul 13;11(1):3495. doi: 10.1038/s41467-020-17212-6.
Nat Commun. 2020.
PMID: 32661310
Free PMC article.
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