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Novel multi-target ligands of dopamine and serotonin receptors for the treatment of schizophrenia based on indazole and piperazine scaffolds-synthesis, biological activity, and structural evaluation.
Stępnicki P, Wronikowska-Denysiuk O, Zięba A, Targowska-Duda KM, Bartyzel A, Wróbel MZ, Wróbel TM, Szałaj K, Chodkowski A, Mirecka K, Budzyńska B, Fornal E, Turło J, Castro M, Kaczor AA. Stępnicki P, et al. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2209828. doi: 10.1080/14756366.2023.2209828. J Enzyme Inhib Med Chem. 2023. PMID: 37184096 Free PMC article.
Discovery of novel arylpiperazine-based DA/5-HT modulators as potential antipsychotic agents - Design, synthesis, structural studies and pharmacological profiling.
Stępnicki P, Targowska-Duda KM, Martínez AL, Zięba A, Wronikowska-Denysiuk O, Wróbel MZ, Bartyzel A, Trzpil A, Wróbel TM, Chodkowski A, Mirecka K, Karcz T, Szczepańska K, Loza MI, Budzyńska B, Turło J, Handzlik J, Fornal E, Poleszak E, Castro M, Kaczor AA. Stępnicki P, et al. Eur J Med Chem. 2023 Apr 5;252:115285. doi: 10.1016/j.ejmech.2023.115285. Epub 2023 Mar 17. Eur J Med Chem. 2023. PMID: 37027998
Funnel metadynamics and behavioral studies reveal complex effect of D2AAK1 ligand on anxiety-like processes.
Bartuzi D, Kędzierska E, Targowska-Duda KM, Koszła O, Wróbel TM, Jademyr S, Karcz T, Szczepańska K, Stępnicki P, Wronikowska-Denysiuk O, Biała G, Handzlik J, Kristensen JL, Poso A, Kaczor AA. Bartuzi D, et al. Among authors: stepnicki p. Sci Rep. 2022 Dec 7;12(1):21192. doi: 10.1038/s41598-022-25478-7. Sci Rep. 2022. PMID: 36476619 Free PMC article.
Overcoming Depression with 5-HT2A Receptor Ligands.
Zięba A, Stępnicki P, Matosiuk D, Kaczor AA. Zięba A, et al. Among authors: stepnicki p. Int J Mol Sci. 2021 Dec 21;23(1):10. doi: 10.3390/ijms23010010. Int J Mol Sci. 2021. PMID: 35008436 Free PMC article. Review.
17 results