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Synthesis of C-5a-substituted derivatives of 4-epi-isofagomine: notable β-galactosidase inhibitors and activity promotors of GM1-gangliosidosis related human lysosomal β-galactosidase mutant R201C.
Thonhofer M, Weber P, Gonzalez Santana A, Tysoe C, Fischer R, Pabst BM, Paschke E, Schalli M, Stütz AE, Tschernutter M, Windischhofer W, Withers SG. Thonhofer M, et al. Among authors: stutz ae. Carbohydr Res. 2016 Jun 24;429:71-80. doi: 10.1016/j.carres.2016.03.020. Epub 2016 Mar 31. Carbohydr Res. 2016. PMID: 27063389
Probing the aglycon binding site of a beta-glucosidase: a collection of C-1-modified 2,5-dideoxy-2,5-imino-D-mannitol derivatives and their structure-activity relationships as competitive inhibitors.
Wrodnigg TM, Diness F, Gruber C, Häusler H, Lundt I, Rupitz K, Steiner AJ, Stütz AE, Tarling CA, Withers SG, Wölfler H. Wrodnigg TM, et al. Among authors: stutz ae. Bioorg Med Chem. 2004 Jul 1;12(13):3485-95. doi: 10.1016/j.bmc.2004.04.037. Bioorg Med Chem. 2004. PMID: 15186833
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