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CTSH regulates β-cell function and disease progression in newly diagnosed type 1 diabetes patients.
Fløyel T, Brorsson C, Nielsen LB, Miani M, Bang-Berthelsen CH, Friedrichsen M, Overgaard AJ, Berchtold LA, Wiberg A, Poulsen P, Hansen L, Rosinger S, Boehm BO, Ram R, Nguyen Q, Mehta M, Morahan G, Concannon P, Bergholdt R, Nielsen JH, Reinheckel T, von Herrath M, Vaag A, Eizirik DL, Mortensen HB, Størling J, Pociot F. Fløyel T, et al. Among authors: storling j. Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10305-10. doi: 10.1073/pnas.1402571111. Epub 2014 Jun 30. Proc Natl Acad Sci U S A. 2014. PMID: 24982147 Free PMC article. Clinical Trial.
Type 1 database mellitus: an inflammatory disease of the islet.
Bergholdt R, Heding P, Nielsen K, Nolsøe R, Sparre T, Størling J, Nerup J, Pociot F, Mandrup-Poulsen T. Bergholdt R, et al. Among authors: storling j. Adv Exp Med Biol. 2004;552:129-53. Adv Exp Med Biol. 2004. PMID: 15622962 Review. No abstract available.
Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells.
Cardozo AK, Ortis F, Storling J, Feng YM, Rasschaert J, Tonnesen M, Van Eylen F, Mandrup-Poulsen T, Herchuelz A, Eizirik DL. Cardozo AK, et al. Among authors: storling j. Diabetes. 2005 Feb;54(2):452-61. doi: 10.2337/diabetes.54.2.452. Diabetes. 2005. PMID: 15677503
Immune-mediated beta-cell destruction in vitro and in vivo-A pivotal role for galectin-3.
Karlsen AE, Størling ZM, Sparre T, Larsen MR, Mahmood A, Størling J, Roepstorff P, Wrzesinski K, Larsen PM, Fey S, Nielsen K, Heding P, Ricordi C, Johannesen J, Kristiansen OP, Christensen UB, Kockum I, Luthman H, Nerup J, Pociot F. Karlsen AE, et al. Among authors: storling zm, storling j. Biochem Biophys Res Commun. 2006 May 26;344(1):406-15. doi: 10.1016/j.bbrc.2006.03.105. Epub 2006 Mar 29. Biochem Biophys Res Commun. 2006. PMID: 16600178
The Fas pathway is involved in pancreatic beta cell secretory function.
Schumann DM, Maedler K, Franklin I, Konrad D, Størling J, Böni-Schnetzler M, Gjinovci A, Kurrer MO, Gauthier BR, Bosco D, Andres A, Berney T, Greter M, Becher B, Chervonsky AV, Halban PA, Mandrup-Poulsen T, Wollheim CB, Donath MY. Schumann DM, et al. Among authors: storling j. Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2861-6. doi: 10.1073/pnas.0611487104. Epub 2007 Feb 13. Proc Natl Acad Sci U S A. 2007. PMID: 17299038 Free PMC article.
Huntingtin-interacting protein 14 is a type 1 diabetes candidate protein regulating insulin secretion and beta-cell apoptosis.
Berchtold LA, Størling ZM, Ortis F, Lage K, Bang-Berthelsen C, Bergholdt R, Hald J, Brorsson CA, Eizirik DL, Pociot F, Brunak S, Størling J. Berchtold LA, et al. Among authors: storling zm, storling j. Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):E681-8. doi: 10.1073/pnas.1104384108. Epub 2011 Jun 24. Proc Natl Acad Sci U S A. 2011. PMID: 21705657 Free PMC article.
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