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Regulation of ferroptotic cancer cell death by GPX4.
Cell. 2014 Jan 16;156(1-2):317-331. doi: 10.1016/j.cell.2013.12.010.
Cell. 2014.
PMID: 24439385
Free PMC article.
Identification of a small molecule that induces ATG5-and-cathepsin-l-dependent cell death and modulates polyglutamine toxicity.
Varma H, Gangadhar NM, Letso RR, Wolpaw AJ, Sriramaratnam R, Stockwell BR.
Varma H, et al. Among authors: sriramaratnam r.
Exp Cell Res. 2013 Jul 15;319(12):1759-1773. doi: 10.1016/j.yexcr.2013.03.019. Epub 2013 Apr 12.
Exp Cell Res. 2013.
PMID: 23588206
Free PMC article.
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Identification of PDE6D as a molecular target of anecortave acetate via a methotrexate-anchored yeast three-hybrid screen.
Shepard AR, Conrow RE, Pang IH, Jacobson N, Rezwan M, Rutschmann K, Auerbach D, Sriramaratnam R, Cornish VW.
Shepard AR, et al. Among authors: sriramaratnam r.
ACS Chem Biol. 2013 Mar 15;8(3):549-58. doi: 10.1021/cb300296m. Epub 2013 Jan 9.
ACS Chem Biol. 2013.
PMID: 23301619
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Covalent Proximity Scanning of a Distal Cysteine to Target PI3Kα.
Borsari C, Keles E, McPhail JA, Schaefer A, Sriramaratnam R, Goch W, Schaefer T, De Pascale M, Bal W, Gstaiger M, Burke JE, Wymann MP.
Borsari C, et al. Among authors: sriramaratnam r.
J Am Chem Soc. 2022 Apr 13;144(14):6326-6342. doi: 10.1021/jacs.1c13568. Epub 2022 Mar 30.
J Am Chem Soc. 2022.
PMID: 35353516
Free PMC article.
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4-(Difluoromethyl)-5-(4-((3R,5S)-3,5-dimethylmorpholino)-6-((R)-3-methylmorpholino)-1,3,5-triazin-2-yl)pyridin-2-amine (PQR626), a Potent, Orally Available, and Brain-Penetrant mTOR Inhibitor for the Treatment of Neurological Disorders.
Borsari C, Keles E, Rageot D, Treyer A, Bohnacker T, Bissegger L, De Pascale M, Melone A, Sriramaratnam R, Beaufils F, Hamburger M, Hebeisen P, Löscher W, Fabbro D, Hillmann P, Wymann MP.
Borsari C, et al. Among authors: sriramaratnam r.
J Med Chem. 2020 Nov 25;63(22):13595-13617. doi: 10.1021/acs.jmedchem.0c00620. Epub 2020 Nov 9.
J Med Chem. 2020.
PMID: 33166139
Free article.
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(S)-4-(Difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine (PQR530), a Potent, Orally Bioavailable, and Brain-Penetrable Dual Inhibitor of Class I PI3K and mTOR Kinase.
Rageot D, Bohnacker T, Keles E, McPhail JA, Hoffmann RM, Melone A, Borsari C, Sriramaratnam R, Sele AM, Beaufils F, Hebeisen P, Fabbro D, Hillmann P, Burke JE, Wymann MP.
Rageot D, et al. Among authors: sriramaratnam r.
J Med Chem. 2019 Jul 11;62(13):6241-6261. doi: 10.1021/acs.jmedchem.9b00525. Epub 2019 Jun 20.
J Med Chem. 2019.
PMID: 31244112
Free article.
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