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New aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the hydroxytriazole scaffold.
Pippione AC, Kilic-Kurt Z, Kovachka S, Sainas S, Rolando B, Denasio E, Pors K, Adinolfi S, Zonari D, Bagnati R, Lolli ML, Spyrakis F, Oliaro-Bosso S, Boschi D. Pippione AC, et al. Among authors: spyrakis f. Eur J Med Chem. 2022 Jul 5;237:114366. doi: 10.1016/j.ejmech.2022.114366. Epub 2022 Apr 13. Eur J Med Chem. 2022. PMID: 35447434 Free article.
PROTAC-Induced Glycogen Synthase Kinase 3β Degradation as a Potential Therapeutic Strategy for Alzheimer's Disease.
Guardigni M, Pruccoli L, Santini A, Simone A, Bersani M, Spyrakis F, Frabetti F, Uliassi E, Andrisano V, Pagliarani B, Fernández-Gómez P, Palomo V, Bolognesi ML, Tarozzi A, Milelli A. Guardigni M, et al. Among authors: spyrakis f. ACS Chem Neurosci. 2023 Jun 7;14(11):1963-1970. doi: 10.1021/acschemneuro.3c00096. Epub 2023 May 23. ACS Chem Neurosci. 2023. PMID: 37218653 Free PMC article.
Tuning the Hydrophobicity of a Mitochondria-Targeted NO Photodonor.
Sodano F, Rolando B, Spyrakis F, Failla M, Lazzarato L, Gazzano E, Riganti C, Fruttero R, Gasco A, Sortino S. Sodano F, et al. Among authors: spyrakis f. ChemMedChem. 2018 Jun 20;13(12):1238-1245. doi: 10.1002/cmdc.201800088. Epub 2018 May 8. ChemMedChem. 2018. PMID: 29633541
Fluorescent Nitric Oxide Photodonors Based on BODIPY and Rhodamine Antennae.
Parisi C, Failla M, Fraix A, Rolando B, Gianquinto E, Spyrakis F, Gazzano E, Riganti C, Lazzarato L, Fruttero R, Gasco A, Sortino S. Parisi C, et al. Among authors: spyrakis f. Chemistry. 2019 Aug 22;25(47):11080-11084. doi: 10.1002/chem.201902062. Epub 2019 Jul 4. Chemistry. 2019. PMID: 31074543
Paracetamol-Galactose Conjugate: A Novel Prodrug for an Old Analgesic Drug.
Sodano F, Lazzarato L, Rolando B, Spyrakis F, De Caro C, Magliocca S, Marabello D, Chegaev K, Gazzano E, Riganti C, Calignano A, Russo R, Rimoli MG. Sodano F, et al. Among authors: spyrakis f. Mol Pharm. 2019 Oct 7;16(10):4181-4189. doi: 10.1021/acs.molpharmaceut.9b00508. Epub 2019 Sep 12. Mol Pharm. 2019. PMID: 31465230 Free article.
DNA-Targeted NO Release Photoregulated by Green Light.
Parisi C, Fraix A, Guglielmo S, Spyrakis F, Rolando B, Lazzarato L, Fruttero R, Gasco A, Sortino S. Parisi C, et al. Among authors: spyrakis f. Chemistry. 2020 Oct 27;26(60):13627-13633. doi: 10.1002/chem.202001538. Epub 2020 Sep 28. Chemistry. 2020. PMID: 32453464
113 results