Spring DR - Search Results

1

Downfalls of Chemical Probes Acting at the Kinase ATP-Site: CK2 as a Case Study.

Atkinson EL, Iegre J, Brear PD, Zhabina EA, Hyvönen M, Spring DR. Atkinson EL, et al. Among authors: spring dr. Molecules. 2021 Mar 31;26(7):1977. doi: 10.3390/molecules26071977. Molecules. 2021. PMID: 33807474 Free PMC article. Review.

2

Design and synthesis of a biotinylated chemical probe for detecting the molecular targets of an inhibitor of the production of the Pseudomonas aeruginosa virulence factor pyocyanin.

Baker YR, Galloway WR, Hodgkinson JT, Spring DR. Baker YR, et al. Among authors: spring dr. Molecules. 2013 Sep 25;18(10):11783-96. doi: 10.3390/molecules181011783. Molecules. 2013. PMID: 24071985 Free PMC article.

3

Double Strain-Promoted Macrocyclization for the Rapid Selection of Cell-Active Stapled Peptides.

Lau YH, Wu Y, Rossmann M, Tan BX, de Andrade P, Tan YS, Verma C, McKenzie GJ, Venkitaraman AR, Hyvönen M, Spring DR. Lau YH, et al. Among authors: spring dr. Angew Chem Int Ed Engl. 2015 Dec 14;54(51):15410-3. doi: 10.1002/anie.201508416. Epub 2015 Nov 2. Angew Chem Int Ed Engl. 2015. PMID: 26768531 Free PMC article.

4

Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2.

Janeček M, Rossmann M, Sharma P, Emery A, Huggins DJ, Stockwell SR, Stokes JE, Tan YS, Almeida EG, Hardwick B, Narvaez AJ, Hyvönen M, Spring DR, McKenzie GJ, Venkitaraman AR. Janeček M, et al. Among authors: spring dr. Sci Rep. 2016 Jun 24;6:28528. doi: 10.1038/srep28528. Sci Rep. 2016. PMID: 27339427 Free PMC article.

5

Combinatorial Synthesis of Structurally Diverse Triazole-Bridged Flavonoid Dimers and Trimers.

Sum TH, Sum TJ, Galloway WR, Collins S, Twigg DG, Hollfelder F, Spring DR. Sum TH, et al. Among authors: spring dr. Molecules. 2016 Sep 16;21(9):1230. doi: 10.3390/molecules21091230. Molecules. 2016. PMID: 27649131 Free PMC article.

6

Macrocyclized Extended Peptides: Inhibiting the Substrate-Recognition Domain of Tankyrase.

Xu W, Lau YH, Fischer G, Tan YS, Chattopadhyay A, de la Roche M, Hyvönen M, Verma C, Spring DR, Itzhaki LS. Xu W, et al. Among authors: spring dr. J Am Chem Soc. 2017 Feb 15;139(6):2245-2256. doi: 10.1021/jacs.6b10234. Epub 2017 Feb 7. J Am Chem Soc. 2017. PMID: 28084734 Free PMC article.

7

Specific inhibition of CK2α from an anchor outside the active site.

Brear P, De Fusco C, Hadje Georgiou K, Francis-Newton NJ, Stubbs CJ, Sore HF, Venkitaraman AR, Abell C, Spring DR, Hyvönen M. Brear P, et al. Among authors: spring dr. Chem Sci. 2016 Nov 1;7(11):6839-6845. doi: 10.1039/c6sc02335e. Epub 2016 Jul 12. Chem Sci. 2016. PMID: 28451126 Free PMC article.

8

A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066.

De Fusco C, Brear P, Iegre J, Georgiou KH, Sore HF, Hyvönen M, Spring DR. De Fusco C, et al. Among authors: spring dr. Bioorg Med Chem. 2017 Jul 1;25(13):3471-3482. doi: 10.1016/j.bmc.2017.04.037. Epub 2017 Apr 30. Bioorg Med Chem. 2017. PMID: 28495381 Free PMC article.

9

Computationally-guided optimization of small-molecule inhibitors of the Aurora A kinase-TPX2 protein-protein interaction.

Cole DJ, Janecek M, Stokes JE, Rossmann M, Faver JC, McKenzie GJ, Venkitaraman AR, Hyvönen M, Spring DR, Huggins DJ, Jorgensen WL. Cole DJ, et al. Among authors: spring dr. Chem Commun (Camb). 2017 Aug 17;53(67):9372-9375. doi: 10.1039/c7cc05379g. Chem Commun (Camb). 2017. PMID: 28787041 Free PMC article.

10

Using Peptidomimetics and Constrained Peptides as Valuable Tools for Inhibiting Protein⁻Protein Interactions.

Robertson NS, Spring DR. Robertson NS, et al. Among authors: spring dr. Molecules. 2018 Apr 19;23(4):959. doi: 10.3390/molecules23040959. Molecules. 2018. PMID: 29671834 Free PMC article. Review.

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