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Efficacy and safety of ciclosporin versus methotrexate in the treatment of severe atopic dermatitis in children and young people (TREAT): a multicentre parallel group assessor-blinded clinical trial.
Flohr C, Rosala-Hallas A, Jones AP, Beattie P, Baron S, Browne F, Brown SJ, Gach JE, Greenblatt D, Hearn R, Hilger E, Esdaile B, Cork MJ, Howard E, Lovgren ML, August S, Ashoor F, Williamson PR, McPherson T, O'Kane D, Ravenscroft J, Shaw L, Sinha MD, Spowart C, Taams LS, Thomas BR, Wan M, Sach TH, Irvine AD; TREAT Trial Investigators. Flohr C, et al. Among authors: spowart c. Br J Dermatol. 2023 Nov 16;189(6):674-684. doi: 10.1093/bjd/ljad281. Br J Dermatol. 2023. PMID: 37722926 Free article. Clinical Trial.
A randomized controlled trial protocol assessing the effectiveness, safety and cost-effectiveness of methotrexate vs. ciclosporin in the treatment of severe atopic eczema in children: the TREatment of severe Atopic eczema Trial (TREAT).
Irvine AD, Jones AP, Beattie P, Baron S, Browne F, Ashoor F, O'Neill L, Rosala-Hallas A, Sach T, Spowart C, Taams L, Walker C, Wan M, Webb N, Williamson P, Flohr C; TREAT Trial Investigators. Irvine AD, et al. Among authors: spowart c. Br J Dermatol. 2018 Dec;179(6):1297-1306. doi: 10.1111/bjd.16717. Epub 2018 Oct 28. Br J Dermatol. 2018. PMID: 29727479
Duration of intravenous antibiotic therapy for children with acute osteomyelitis or septic arthritis: a feasibility study.
de Graaf H, Sukhtankar P, Arch B, Ahmad N, Lees A, Bennett A, Spowart C, Hickey H, Jeanes A, Armon K, Riordan A, Herberg J, Hackett S, Gamble C, Shingadia D, Pallett A, Clarke SC, Henman P, Emonts M, Sharland M, Finn A, Pollard AJ, Powell C, Marsh P, Ballinger C, Williamson PR, Clarke NM, Faust SN. de Graaf H, et al. Among authors: spowart c. Health Technol Assess. 2017 Sep;21(48):1-164. doi: 10.3310/hta21480. Health Technol Assess. 2017. PMID: 28862129 Free PMC article.
Telmisartan to reduce insulin resistance in HIV-positive individuals on combination antiretroviral therapy: the TAILoR dose-ranging Phase II RCT.
Pushpakom S, Kolamunnage-Dona R, Taylor C, Foster T, Spowart C, Garcia-Finana M, Kemp GJ, Jaki T, Khoo S, Williamson P, Pirmohamed M. Pushpakom S, et al. Among authors: spowart c. Southampton (UK): NIHR Journals Library; 2019 Jul. Southampton (UK): NIHR Journals Library; 2019 Jul. PMID: 31318501 Free Books & Documents. Review.
Telmisartan and Insulin Resistance in HIV (TAILoR): protocol for a dose-ranging phase II randomised open-labelled trial of telmisartan as a strategy for the reduction of insulin resistance in HIV-positive individuals on combination antiretroviral therapy.
Pushpakom SP, Taylor C, Kolamunnage-Dona R, Spowart C, Vora J, García-Fiñana M, Kemp GJ, Whitehead J, Jaki T, Khoo S, Williamson P, Pirmohamed M. Pushpakom SP, et al. Among authors: spowart c. BMJ Open. 2015 Oct 15;5(10):e009566. doi: 10.1136/bmjopen-2015-009566. BMJ Open. 2015. PMID: 26474943 Free PMC article. Clinical Trial.
Rationale and design of a randomised trial of trientine in patients with hypertrophic cardiomyopathy.
Farrant J, Dodd S, Vaughan C, Reid A, Schmitt M, Garratt C, Akhtar M, Mahmod M, Neubauer S, Cooper RM, Prasad SK, Singh A, Valkovič L, Raman B, Ashkir Z, Clayton D, Baroja O, Duran B, Spowart C, Bedson E, Naish JH, Harrington C, Miller CA; TEMPEST investigators. Farrant J, et al. Among authors: spowart c. Heart. 2023 Jul 12;109(15):1175-1182. doi: 10.1136/heartjnl-2022-322271. Heart. 2023. PMID: 37137675 Free PMC article. Clinical Trial.
Prospective multicentre randomised, double-blind, equivalence study comparing clonidine and midazolam as intravenous sedative agents in critically ill children: the SLEEPS (Safety profiLe, Efficacy and Equivalence in Paediatric intensive care Sedation) study.
Wolf A, McKay A, Spowart C, Granville H, Boland A, Petrou S, Sutherland A, Gamble C. Wolf A, et al. Among authors: spowart c. Health Technol Assess. 2014 Dec;18(71):1-212. doi: 10.3310/hta18710. Health Technol Assess. 2014. PMID: 26099138 Free PMC article. Clinical Trial.
Changing Agendas on Sleep, Treatment and Learning in Epilepsy (CASTLE) Sleep-E: a protocol for a randomised controlled trial comparing an online behavioural sleep intervention with standard care in children with Rolandic epilepsy.
Al-Najjar N, Bray L, Carter B, Castle AP, Collingwood A, Cook G, Crudgington H, Currier J, Dietz KC, Hardy WAS, Hiscock H, Hughes D, Morris C, Roberts D, Rouncefield-Swales A, Saron H, Spowart C, Stibbs-Eaton L, Tudur Smith C, Watson V, Whittle L, Wiggs L, Wood E, Gringras P, Pal DK. Al-Najjar N, et al. Among authors: spowart c. BMJ Open. 2023 Mar 10;13(3):e065769. doi: 10.1136/bmjopen-2022-065769. BMJ Open. 2023. PMID: 36898757 Free PMC article.
The impact of parent treatment preference and other factors on recruitment: lessons learned from a paediatric epilepsy randomised controlled trial.
Carter B, Bray L, Al-Najjar N, Piella AT, Tudur-Smith C, Spowart C, Collingwood A, Crudgington H, Currier J, Hughes DA, Wood E, Martin R, Morris C, Roberts D, Rouncefield-Swales A, Sutherland H, Watson V, Cook G, Wiggs L, Gringras P, Pal D. Carter B, et al. Among authors: spowart c. Trials. 2023 Feb 6;24(1):83. doi: 10.1186/s13063-023-07091-9. Trials. 2023. PMID: 36747248 Free PMC article. Clinical Trial.
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