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Pharmacological induction of membrane lipid poly-unsaturation sensitizes melanoma to ROS inducers and overcomes acquired resistance to targeted therapy.
J Exp Clin Cancer Res. 2023 Apr 19;42(1):92. doi: 10.1186/s13046-023-02664-7.
J Exp Clin Cancer Res. 2023.
PMID: 37072838
Free PMC article.
A palmitate-rich metastatic niche enables metastasis growth via p65 acetylation resulting in pro-metastatic NF-κB signaling.
Altea-Manzano P, Doglioni G, Liu Y, Cuadros AM, Nolan E, Fernández-García J, Wu Q, Planque M, Laue KJ, Cidre-Aranaz F, Liu XZ, Marin-Bejar O, Van Elsen J, Vermeire I, Broekaert D, Demeyer S, Spotbeen X, Idkowiak J, Montagne A, Demicco M, Alkan HF, Rabas N, Riera-Domingo C, Richard F, Geukens T, De Schepper M, Leduc S, Hatse S, Lambrechts Y, Kay EJ, Lilla S, Alekseenko A, Geldhof V, Boeckx B, de la Calle Arregui C, Floris G, Swinnen JV, Marine JC, Lambrechts D, Pelechano V, Mazzone M, Zanivan S, Cools J, Wildiers H, Baud V, Grünewald TGP, Ben-David U, Desmedt C, Malanchi I, Fendt SM.
Altea-Manzano P, et al. Among authors: spotbeen x.
Nat Cancer. 2023 Mar;4(3):344-364. doi: 10.1038/s43018-023-00513-2. Epub 2023 Feb 2.
Nat Cancer. 2023.
PMID: 36732635
Free PMC article.
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Unravelling Prostate Cancer Heterogeneity Using Spatial Approaches to Lipidomics and Transcriptomics.
Mutuku SM, Spotbeen X, Trim PJ, Snel MF, Butler LM, Swinnen JV.
Mutuku SM, et al. Among authors: spotbeen x.
Cancers (Basel). 2022 Mar 27;14(7):1702. doi: 10.3390/cancers14071702.
Cancers (Basel). 2022.
PMID: 35406474
Free PMC article.
Review.
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Lipidomic Profiling of Clinical Prostate Cancer Reveals Targetable Alterations in Membrane Lipid Composition.
Butler LM, Mah CY, Machiels J, Vincent AD, Irani S, Mutuku SM, Spotbeen X, Bagadi M, Waltregny D, Moldovan M, Dehairs J, Vanderhoydonc F, Bloch K, Das R, Stahl J, Kench JG, Gevaert T, Derua R, Waelkens E, Nassar ZD, Selth LA, Trim PJ, Snel MF, Lynn DJ, Tilley WD, Horvath LG, Centenera MM, Swinnen JV.
Butler LM, et al. Among authors: spotbeen x.
Cancer Res. 2021 Oct 1;81(19):4981-4993. doi: 10.1158/0008-5472.CAN-20-3863. Epub 2021 Aug 6.
Cancer Res. 2021.
PMID: 34362796
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Removal of optimal cutting temperature (O.C.T.) compound from embedded tissue for MALDI imaging of lipids.
Truong JXM, Spotbeen X, White J, Swinnen JV, Butler LM, Snel MF, Trim PJ.
Truong JXM, et al. Among authors: spotbeen x.
Anal Bioanal Chem. 2021 Apr;413(10):2695-2708. doi: 10.1007/s00216-020-03128-z. Epub 2021 Feb 9.
Anal Bioanal Chem. 2021.
PMID: 33564925
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