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Inhibition of Crif1 protects fatty acid-induced POMC neuron-like cell-line damage by increasing CPT-1 function.
Regina-Ferreira L, Valdivieso-Rivera F, Angelim MKSC, Menezes Dos Reis L, Furino VO, Morari J, Maia de Sousa L, Consonni SR, Sponton CH, Moraes-Vieira PM, Velloso LA. Regina-Ferreira L, et al. Among authors: sponton ch. Am J Physiol Endocrinol Metab. 2024 May 1;326(5):E681-E695. doi: 10.1152/ajpendo.00420.2023. Epub 2024 Apr 10. Am J Physiol Endocrinol Metab. 2024. PMID: 38597829
The regulation of glucose and lipid homeostasis via PLTP as a mediator of BAT-liver communication.
Sponton CH, Hosono T, Taura J, Jedrychowski MP, Yoneshiro T, Wang Q, Takahashi M, Matsui Y, Ikeda K, Oguri Y, Tajima K, Shinoda K, Pradhan RN, Chen Y, Brown Z, Roberts LS, Ward CC, Taoka H, Yokoyama Y, Watanabe M, Karasawa H, Nomura DK, Kajimura S. Sponton CH, et al. EMBO Rep. 2020 Sep 3;21(9):e49828. doi: 10.15252/embr.201949828. Epub 2020 Jul 16. EMBO Rep. 2020. PMID: 32672883 Free PMC article.
BCAA catabolism in brown fat controls energy homeostasis through SLC25A44.
Yoneshiro T, Wang Q, Tajima K, Matsushita M, Maki H, Igarashi K, Dai Z, White PJ, McGarrah RW, Ilkayeva OR, Deleye Y, Oguri Y, Kuroda M, Ikeda K, Li H, Ueno A, Ohishi M, Ishikawa T, Kim K, Chen Y, Sponton CH, Pradhan RN, Majd H, Greiner VJ, Yoneshiro M, Brown Z, Chondronikola M, Takahashi H, Goto T, Kawada T, Sidossis L, Szoka FC, McManus MT, Saito M, Soga T, Kajimura S. Yoneshiro T, et al. Among authors: sponton ch. Nature. 2019 Aug;572(7771):614-619. doi: 10.1038/s41586-019-1503-x. Epub 2019 Aug 21. Nature. 2019. PMID: 31435015 Free PMC article.
Opposing action of NCoR1 and PGC-1α in mitochondrial redox homeostasis.
Lima TI, Guimarães DSPSF, Oliveira AG, Araujo H, Sponton CHG, Souza-Pinto NC, Saito Â, Figueira ACM, Palameta S, Bajgelman MC, Calixto A, Pinto S, Mori MA, Orofino J, Perissi V, Mottis A, Auwerx J, Silveira LR. Lima TI, et al. Among authors: sponton chg. Free Radic Biol Med. 2019 Nov 1;143:203-208. doi: 10.1016/j.freeradbiomed.2019.08.006. Epub 2019 Aug 10. Free Radic Biol Med. 2019. PMID: 31408725
Essential role of the PGC-1α/PPARβ axis in Ucp3 gene induction.
Lima TI, Guimarães D, Sponton CH, Bajgelman MC, Palameta S, Toscaro JM, Reis O, Silveira LR. Lima TI, et al. Among authors: sponton ch. J Physiol. 2019 Aug;597(16):4277-4291. doi: 10.1113/JP278006. Epub 2019 Jul 17. J Physiol. 2019. PMID: 31228206 Free article.
Thermal stress induces glycolytic beige fat formation via a myogenic state.
Chen Y, Ikeda K, Yoneshiro T, Scaramozza A, Tajima K, Wang Q, Kim K, Shinoda K, Sponton CH, Brown Z, Brack A, Kajimura S. Chen Y, et al. Among authors: sponton ch. Nature. 2019 Jan;565(7738):180-185. doi: 10.1038/s41586-018-0801-z. Epub 2018 Dec 19. Nature. 2019. PMID: 30568302 Free PMC article.
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