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SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2.
Clausen TM, Sandoval DR, Spliid CB, Pihl J, Perrett HR, Painter CD, Narayanan A, Majowicz SA, Kwong EM, McVicar RN, Thacker BE, Glass CA, Yang Z, Torres JL, Golden GJ, Bartels PL, Porell RN, Garretson AF, Laubach L, Feldman J, Yin X, Pu Y, Hauser BM, Caradonna TM, Kellman BP, Martino C, Gordts PLSM, Chanda SK, Schmidt AG, Godula K, Leibel SL, Jose J, Corbett KD, Ward AB, Carlin AF, Esko JD. Clausen TM, et al. Among authors: spliid cb. Cell. 2020 Nov 12;183(4):1043-1057.e15. doi: 10.1016/j.cell.2020.09.033. Epub 2020 Sep 14. Cell. 2020. PMID: 32970989 Free PMC article.
An affinity chromatography and glycoproteomics workflow to profile the chondroitin sulfate proteoglycans that interact with malarial VAR2CSA in the placenta and in cancer.
Toledo AG, Pihl J, Spliid CB, Persson A, Nilsson J, Pereira MA, Gustavsson T, Choudhary S, Oo HZ, Black PC, Daugaard M, Esko JD, Larson G, Salanti A, Clausen TM. Toledo AG, et al. Among authors: spliid cb. Glycobiology. 2020 Dec 9;30(12):989-1002. doi: 10.1093/glycob/cwaa039. Glycobiology. 2020. PMID: 32337544 Free PMC article.
SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2.
Clausen TM, Sandoval DR, Spliid CB, Pihl J, Painter CD, Thacker BE, Glass CA, Narayanan A, Majowicz SA, Zhang Y, Torres JL, Golden GJ, Porell R, Garretson AF, Laubach L, Feldman J, Yin X, Pu Y, Hauser B, Caradonna TM, Kellman BP, Martino C, Gordts PLSM, Leibel SL, Chanda SK, Schmidt AG, Godula K, Jose J, Corbett KD, Ward AB, Carlin AF, Esko JD. Clausen TM, et al. Among authors: spliid cb. bioRxiv [Preprint]. 2020 Jul 14:2020.07.14.201616. doi: 10.1101/2020.07.14.201616. bioRxiv. 2020. PMID: 32699853 Free PMC article. Updated. Preprint.
The Role of Proteoglycans in Cancer Metastasis and Circulating Tumor Cell Analysis.
Ahrens TD, Bang-Christensen SR, Jørgensen AM, Løppke C, Spliid CB, Sand NT, Clausen TM, Salanti A, Agerbæk MØ. Ahrens TD, et al. Among authors: spliid cb. Front Cell Dev Biol. 2020 Aug 26;8:749. doi: 10.3389/fcell.2020.00749. eCollection 2020. Front Cell Dev Biol. 2020. PMID: 32984308 Free PMC article. Review.
Cryo-EM reveals the architecture of placental malaria VAR2CSA and provides molecular insight into chondroitin sulfate binding.
Wang K, Dagil R, Lavstsen T, Misra SK, Spliid CB, Wang Y, Gustavsson T, Sandoval DR, Vidal-Calvo EE, Choudhary S, Agerbaek MØ, Lindorff-Larsen K, Nielsen MA, Theander TG, Sharp JS, Clausen TM, Gourdon P, Salanti A. Wang K, et al. Among authors: spliid cb. Nat Commun. 2021 May 19;12(1):2956. doi: 10.1038/s41467-021-23254-1. Nat Commun. 2021. PMID: 34011972 Free PMC article.
The specificity of the malarial VAR2CSA protein for chondroitin sulfate depends on 4-O-sulfation and ligand accessibility.
Spliid CB, Toledo AG, Sanderson P, Mao Y, Gatto F, Gustavsson T, Choudhary S, Saldanha AL, Vogelsang RP, Gögenur I, Theander TG, Leach FE 3rd, Amster IJ, Esko JD, Salanti A, Clausen TM. Spliid CB, et al. J Biol Chem. 2021 Dec;297(6):101391. doi: 10.1016/j.jbc.2021.101391. Epub 2021 Nov 8. J Biol Chem. 2021. PMID: 34762909 Free PMC article.
Spike-heparan sulfate interactions in SARS-CoV-2 infection.
Kearns FL, Sandoval DR, Casalino L, Clausen TM, Rosenfeld MA, Spliid CB, Amaro RE, Esko JD. Kearns FL, et al. Among authors: spliid cb. Curr Opin Struct Biol. 2022 Oct;76:102439. doi: 10.1016/j.sbi.2022.102439. Epub 2022 Jul 6. Curr Opin Struct Biol. 2022. PMID: 35926454 Free PMC article. Review.
Reformation of the chondroitin sulfate glycocalyx enables progression of AR-independent prostate cancer.
Al-Nakouzi N, Wang CK, Oo HZ, Nelepcu I, Lallous N, Spliid CB, Khazamipour N, Lo J, Truong S, Collins C, Hui D, Esfandnia S, Adomat H, Clausen TM, Gustavsson T, Choudhary S, Dagil R, Corey E, Wang Y, Chauchereau A, Fazli L, Esko JD, Salanti A, Nelson PS, Gleave ME, Daugaard M. Al-Nakouzi N, et al. Among authors: spliid cb. Nat Commun. 2022 Aug 13;13(1):4760. doi: 10.1038/s41467-022-32530-7. Nat Commun. 2022. PMID: 35963852 Free PMC article.
15 results