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Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair.
Bolgi O, Silva-Garcia M, Ross B, Pilla E, Kari V, Killisch M, Spitzner M, Stark N, Lenz C, Weiss K, Donzelli L, Gorrell MD, Grade M, Riemer J, Urlaub H, Dobbelstein M, Huber R, Geiss-Friedlander R. Bolgi O, et al. Among authors: spitzner m. EMBO Rep. 2022 Oct 6;23(10):e54136. doi: 10.15252/embr.202154136. Epub 2022 Aug 1. EMBO Rep. 2022. PMID: 35912982 Free PMC article.
NOTCH Activation via gp130/STAT3 Signaling Confers Resistance to Chemoradiotherapy.
Koerdel K, Spitzner M, Meyer T, Engels N, Krause F, Gaedcke J, Conradi LC, Haubrock M, Beißbarth T, Leha A, Johnsen SA, Ghadimi BM, Rose-John S, Grade M, Wienands J. Koerdel K, et al. Among authors: spitzner m. Cancers (Basel). 2021 Jan 26;13(3):455. doi: 10.3390/cancers13030455. Cancers (Basel). 2021. PMID: 33530306 Free PMC article.
Hepatic arterial infusion of irinotecan and EmboCept® S results in high tumor concentration of SN-38 in a rat model of colorectal liver metastases.
Kauffels A, Kitzmüller M, Gruber A, Nowack H, Bohnenberger H, Spitzner M, Kuthning A, Sprenger T, Czejka M, Ghadimi M, Sperling J. Kauffels A, et al. Among authors: spitzner m. Clin Exp Metastasis. 2019 Feb;36(1):57-66. doi: 10.1007/s10585-019-09954-5. Epub 2019 Jan 24. Clin Exp Metastasis. 2019. PMID: 30680598
The histone methyltransferase DOT1L is required for proper DNA damage response, DNA repair, and modulates chemotherapy responsiveness.
Kari V, Raul SK, Henck JM, Kitz J, Kramer F, Kosinsky RL, Übelmesser N, Mansour WY, Eggert J, Spitzner M, Najafova Z, Bastians H, Grade M, Gaedcke J, Wegwitz F, Johnsen SA. Kari V, et al. Among authors: spitzner m. Clin Epigenetics. 2019 Jan 7;11(1):4. doi: 10.1186/s13148-018-0601-1. Clin Epigenetics. 2019. PMID: 30616689 Free PMC article.
Chemoradiotherapy Resistance in Colorectal Cancer Cells is Mediated by Wnt/β-catenin Signaling.
Emons G, Spitzner M, Reineke S, Möller J, Auslander N, Kramer F, Hu Y, Beissbarth T, Wolff HA, Rave-Fränk M, Heßmann E, Gaedcke J, Ghadimi BM, Johnsen SA, Ried T, Grade M. Emons G, et al. Among authors: spitzner m. Mol Cancer Res. 2017 Nov;15(11):1481-1490. doi: 10.1158/1541-7786.MCR-17-0205. Epub 2017 Aug 15. Mol Cancer Res. 2017. PMID: 28811361 Free PMC article.
32 results