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Page 1
Disruption of sugar nucleotide clearance is a therapeutic vulnerability of cancer cells.
Doshi MB, Lee N, Tseyang T, Ponomarova O, Goel HL, Spears M, Li R, Zhu LJ, Ashwood C, Simin K, Jang C, Mercurio AM, Walhout AJM, Spinelli JB, Kim D. Doshi MB, et al. Among authors: spinelli jb. Nature. 2023 Nov;623(7987):625-632. doi: 10.1038/s41586-023-06676-3. Epub 2023 Oct 25. Nature. 2023. PMID: 37880368 Free PMC article.
Selenium reduction of ubiquinone via SQOR suppresses ferroptosis.
Lee N, Park SJ, Lange M, Tseyang T, Doshi MB, Kim TY, Song Y, Kim DI, Greer PL, Olzmann JA, Spinelli JB, Kim D. Lee N, et al. Among authors: spinelli jb. Nat Metab. 2024 Feb;6(2):343-358. doi: 10.1038/s42255-024-00974-4. Epub 2024 Feb 13. Nat Metab. 2024. PMID: 38351124
Small-Molecule Screen Identifies De Novo Nucleotide Synthesis as a Vulnerability of Cells Lacking SIRT3.
Gonzalez Herrera KN, Zaganjor E, Ishikawa Y, Spinelli JB, Yoon H, Lin JR, Satterstrom FK, Ringel A, Mulei S, Souza A, Gorham JM, Benson CC, Seidman JG, Sorger PK, Clish CB, Haigis MC. Gonzalez Herrera KN, et al. Among authors: spinelli jb. Cell Rep. 2018 Feb 20;22(8):1945-1955. doi: 10.1016/j.celrep.2018.01.076. Cell Rep. 2018. PMID: 29466723 Free PMC article.
Accumulation of succinate controls activation of adipose tissue thermogenesis.
Mills EL, Pierce KA, Jedrychowski MP, Garrity R, Winther S, Vidoni S, Yoneshiro T, Spinelli JB, Lu GZ, Kazak L, Banks AS, Haigis MC, Kajimura S, Murphy MP, Gygi SP, Clish CB, Chouchani ET. Mills EL, et al. Among authors: spinelli jb. Nature. 2018 Aug;560(7716):102-106. doi: 10.1038/s41586-018-0353-2. Epub 2018 Jul 18. Nature. 2018. PMID: 30022159 Free PMC article.
The dynamic clustering of insulin receptor underlies its signaling and is disrupted in insulin resistance.
Dall'Agnese A, Platt JM, Zheng MM, Friesen M, Dall'Agnese G, Blaise AM, Spinelli JB, Henninger JE, Tevonian EN, Hannett NM, Lazaris C, Drescher HK, Bartsch LM, Kilgore HR, Jaenisch R, Griffith LG, Cisse II, Jeppesen JF, Lee TI, Young RA. Dall'Agnese A, et al. Among authors: spinelli jb. Nat Commun. 2022 Dec 6;13(1):7522. doi: 10.1038/s41467-022-35176-7. Nat Commun. 2022. PMID: 36473871 Free PMC article.
Mitochondrial efficiency directs cell fate.
Spinelli JB, Zaganjor E. Spinelli JB, et al. Nat Cell Biol. 2022 Feb;24(2):125-126. doi: 10.1038/s41556-021-00834-3. Nat Cell Biol. 2022. PMID: 35165414 No abstract available.
29 results