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Hypermethylation and global remodelling of DNA methylation is associated with acquired cisplatin resistance in testicular germ cell tumours.
Fazal Z, Singh R, Fang F, Bikorimana E, Baldwin H, Corbet A, Tomlin M, Yerby C, Adra N, Albany C, Lee S, Freemantle SJ, Nephew KP, Christensen BC, Spinella MJ. Fazal Z, et al. Among authors: spinella mj. Epigenetics. 2021 Oct;16(10):1071-1084. doi: 10.1080/15592294.2020.1834926. Epub 2020 Oct 30. Epigenetics. 2021. PMID: 33126827 Free PMC article.
Refractory testicular germ cell tumors are highly sensitive to the second generation DNA methylation inhibitor guadecitabine.
Albany C, Hever-Jardine MP, von Herrmann KM, Yim CY, Tam J, Warzecha JM, Shin L, Bock SE, Curran BS, Chaudhry AS, Kim F, Sandusky GE, Taverna P, Freemantle SJ, Christensen BC, Einhorn LH, Spinella MJ. Albany C, et al. Among authors: spinella mj. Oncotarget. 2017 Jan 10;8(2):2949-2959. doi: 10.18632/oncotarget.13811. Oncotarget. 2017. PMID: 27936464 Free PMC article.
67 results