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Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages.
Runtsch MC, Angiari S, Hooftman A, Wadhwa R, Zhang Y, Zheng Y, Spina JS, Ruzek MC, Argiriadi MA, McGettrick AF, Mendez RS, Zotta A, Peace CG, Walsh A, Chirillo R, Hams E, Fallon PG, Jayamaran R, Dua K, Brown AC, Kim RY, Horvat JC, Hansbro PM, Wang C, O'Neill LAJ. Runtsch MC, et al. Among authors: spina js. Cell Metab. 2022 Mar 1;34(3):487-501.e8. doi: 10.1016/j.cmet.2022.02.002. Cell Metab. 2022. PMID: 35235776 Free article.