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An automated Design-Build-Test-Learn pipeline for enhanced microbial production of fine chemicals.
Carbonell P, Jervis AJ, Robinson CJ, Yan C, Dunstan M, Swainston N, Vinaixa M, Hollywood KA, Currin A, Rattray NJW, Taylor S, Spiess R, Sung R, Williams AR, Fellows D, Stanford NJ, Mulherin P, Le Feuvre R, Barran P, Goodacre R, Turner NJ, Goble C, Chen GG, Kell DB, Micklefield J, Breitling R, Takano E, Faulon JL, Scrutton NS. Carbonell P, et al. Among authors: spiess r. Commun Biol. 2018 Jun 8;1:66. doi: 10.1038/s42003-018-0076-9. eCollection 2018. Commun Biol. 2018. PMID: 30271948 Free PMC article.
Rapid prototyping of microbial production strains for the biomanufacture of potential materials monomers.
Robinson CJ, Carbonell P, Jervis AJ, Yan C, Hollywood KA, Dunstan MS, Currin A, Swainston N, Spiess R, Taylor S, Mulherin P, Parker S, Rowe W, Matthews NE, Malone KJ, Le Feuvre R, Shapira P, Barran P, Turner NJ, Micklefield J, Breitling R, Takano E, Scrutton NS. Robinson CJ, et al. Among authors: spiess r. Metab Eng. 2020 Jul;60:168-182. doi: 10.1016/j.ymben.2020.04.008. Epub 2020 Apr 23. Metab Eng. 2020. PMID: 32335188 Free PMC article.
Mapping the Initial Stages of a Protective Pathway that Enhances Catalytic Turnover by a Lytic Polysaccharide Monooxygenase.
Zhao J, Zhuo Y, Diaz DE, Shanmugam M, Telfer AJ, Lindley PJ, Kracher D, Hayashi T, Seibt LS, Hardy FJ, Manners O, Hedison TM, Hollywood KA, Spiess R, Cain KM, Diaz-Moreno S, Scrutton NS, Tovborg M, Walton PH, Heyes DJ, Green AP. Zhao J, et al. Among authors: spiess r. J Am Chem Soc. 2023 Sep 20;145(37):20672-20682. doi: 10.1021/jacs.3c06607. Epub 2023 Sep 9. J Am Chem Soc. 2023. PMID: 37688545 Free PMC article.
42 results