Spiekermann K - Search Results

1

Prediction of complete remission and survival in acute myeloid leukemia using supervised machine learning.

Eckardt JN, Röllig C, Metzeler K, Kramer M, Stasik S, Georgi JA, Heisig P, Spiekermann K, Krug U, Braess J, Görlich D, Sauerland CM, Woermann B, Herold T, Berdel WE, Hiddemann W, Kroschinsky F, Schetelig J, Platzbecker U, Müller-Tidow C, Sauer T, Serve H, Baldus C, Schäfer-Eckart K, Kaufmann M, Krause S, Hänel M, Schliemann C, Hanoun M, Thiede C, Bornhäuser M, Wendt K, Middeke JM. Eckardt JN, et al. Among authors: spiekermann k. Haematologica. 2023 Mar 1;108(3):690-704. doi: 10.3324/haematol.2021.280027. Haematologica. 2023. PMID: 35708137 Free PMC article.

2

Expression of granulocyte colony-stimulating factor- and granulocyte-macrophage colony-stimulating factor-associated signal transduction proteins of the JAK/STAT pathway in normal granulopoiesis and in blast cells of acute myelogenous leukemia.

Biethahn S, Alves F, Wilde S, Hiddemann W, Spiekermann K. Biethahn S, et al. Among authors: spiekermann k. Exp Hematol. 1999 May;27(5):885-94. doi: 10.1016/s0301-472x(99)00017-x. Exp Hematol. 1999. PMID: 10340405 Free article.

3

Constitutive activation of STAT3 and STAT5 is induced by leukemic fusion proteins with protein tyrosine kinase activity and is sufficient for transformation of hematopoietic precursor cells.

Spiekermann K, Pau M, Schwab R, Schmieja K, Franzrahe S, Hiddemann W. Spiekermann K, et al. Exp Hematol. 2002 Mar;30(3):262-71. doi: 10.1016/s0301-472x(01)00787-1. Exp Hematol. 2002. PMID: 11882364 Free article.

4

The protein tyrosine kinase inhibitor SU5614 inhibits VEGF-induced endothelial cell sprouting and induces growth arrest and apoptosis by inhibition of c-kit in AML cells.

Spiekermann K, Faber F, Voswinckel R, Hiddemann W. Spiekermann K, et al. Exp Hematol. 2002 Jul;30(7):767-73. doi: 10.1016/s0301-472x(02)00837-8. Exp Hematol. 2002. PMID: 12135675 Free article.

5

A new and recurrent activating length mutation in exon 20 of the FLT3 gene in acute myeloid leukemia.

Spiekermann K, Bagrintseva K, Schoch C, Haferlach T, Hiddemann W, Schnittger S. Spiekermann K, et al. Blood. 2002 Nov 1;100(9):3423-5. doi: 10.1182/blood-2002-03-0953. Blood. 2002. PMID: 12384447 Free article.

6

Overexpression and constitutive activation of FLT3 induces STAT5 activation in primary acute myeloid leukemia blast cells.

Spiekermann K, Bagrintseva K, Schwab R, Schmieja K, Hiddemann W. Spiekermann K, et al. Clin Cancer Res. 2003 Jun;9(6):2140-50. Clin Cancer Res. 2003. PMID: 12796379

7

KIT exon 8 mutations associated with core-binding factor (CBF)-acute myeloid leukemia (AML) cause hyperactivation of the receptor in response to stem cell factor.

Kohl TM, Schnittger S, Ellwart JW, Hiddemann W, Spiekermann K. Kohl TM, et al. Among authors: spiekermann k. Blood. 2005 Apr 15;105(8):3319-21. doi: 10.1182/blood-2004-06-2068. Epub 2004 Dec 23. Blood. 2005. PMID: 15618474 Free article.

8

FLT3-ITD-TKD dual mutants associated with AML confer resistance to FLT3 PTK inhibitors and cytotoxic agents by overexpression of Bcl-x(L).

Bagrintseva K, Geisenhof S, Kern R, Eichenlaub S, Reindl C, Ellwart JW, Hiddemann W, Spiekermann K. Bagrintseva K, et al. Among authors: spiekermann k. Blood. 2005 May 1;105(9):3679-85. doi: 10.1182/blood-2004-06-2459. Epub 2004 Dec 30. Blood. 2005. PMID: 15626738 Free article.

9

[Mutations of the gene coding for the receptor tyrosine kinase FLT3 in acute myeloid leukemia. Significance as the disease-specific molecular marker for diagnosis, prognosis and innovative therapy approaches].

Spiekermann K, Hiddemann W, Schnittger S. Spiekermann K, et al. Dtsch Med Wochenschr. 2005 Apr 22;130(16):1020-5. doi: 10.1055/s-2005-866780. Dtsch Med Wochenschr. 2005. PMID: 15830315 Review. German. No abstract available.

10

[Molecular target structures in oncology].

Spiekermann K, Hiddemann W. Spiekermann K, et al. Internist (Berl). 2005 Aug;46(8):847-8, 850-4, 856-60. doi: 10.1007/s00108-005-1463-0. Internist (Berl). 2005. PMID: 16007411 Review. German.

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