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Ergothioneine boosts mitochondrial respiration and exercise performance via direct activation of MPST.
Sprenger HG, Mittenbühler MJ, Sun Y, Van Vranken JG, Schindler S, Jayaraj A, Khetarpal SA, Vargas-Castillo A, Puszynska AM, Spinelli JB, Armani A, Kunchok T, Ryback B, Seo HS, Song K, Sebastian L, O'Young C, Braithwaite C, Dhe-Paganon S, Burger N, Mills EL, Gygi SP, Arthanari H, Chouchani ET, Sabatini DM, Spiegelman BM. Sprenger HG, et al. Among authors: spiegelman bm. bioRxiv [Preprint]. 2024 Apr 10:2024.04.10.588849. doi: 10.1101/2024.04.10.588849. bioRxiv. 2024. PMID: 38645260 Free PMC article. Preprint.
Mustn1 is a smooth muscle cell-secreted microprotein that modulates skeletal muscle extracellular matrix composition.
Ducommun S, Jannig PR, Cervenka I, Murgia M, Mittenbühler MJ, Chernogubova E, Dias JM, Jude B, Correia JC, Van Vranken JG, Ocana-Santero G, Porsmyr-Palmertz M, McCann Haworth S, Martínez-Redondo V, Liu Z, Carlström M, Mann M, Lanner JT, Teixeira AI, Maegdefessel L, Spiegelman BM, Ruas JL. Ducommun S, et al. Among authors: spiegelman bm. Mol Metab. 2024 Apr;82:101912. doi: 10.1016/j.molmet.2024.101912. Epub 2024 Mar 6. Mol Metab. 2024. PMID: 38458566 Free PMC article.
REPTOR and CREBRF encode key regulators of muscle energy metabolism.
Saavedra P, Dumesic PA, Hu Y, Filine E, Jouandin P, Binari R, Wilensky SE, Rodiger J, Wang H, Chen W, Liu Y, Spiegelman BM, Perrimon N. Saavedra P, et al. Among authors: spiegelman bm. Nat Commun. 2023 Aug 15;14(1):4943. doi: 10.1038/s41467-023-40595-1. Nat Commun. 2023. PMID: 37582831 Free PMC article.
Irisin acts through its integrin receptor in a two-step process involving extracellular Hsp90α.
A M, Wales TE, Zhou H, Draga-Coletă SV, Gorgulla C, Blackmore KA, Mittenbühler MJ, Kim CR, Bogoslavski D, Zhang Q, Wang ZF, Jedrychowski MP, Seo HS, Song K, Xu AZ, Sebastian L, Gygi SP, Arthanari H, Dhe-Paganon S, Griffin PR, Engen JR, Spiegelman BM. A M, et al. Among authors: spiegelman bm. Mol Cell. 2023 Jun 1;83(11):1903-1920.e12. doi: 10.1016/j.molcel.2023.05.008. Mol Cell. 2023. PMID: 37267907 Free PMC article.
354 results