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A self-amplifying mRNA SARS-CoV-2 vaccine candidate induces safe and robust protective immunity in preclinical models.
Maruggi G, Mallett CP, Westerbeck JW, Chen T, Lofano G, Friedrich K, Qu L, Sun JT, McAuliffe J, Kanitkar A, Arrildt KT, Wang KF, McBee I, McCoy D, Terry R, Rowles A, Abrahim MA, Ringenberg MA, Gains MJ, Spickler C, Xie X, Zou J, Shi PY, Dutt T, Henao-Tamayo M, Ragan I, Bowen RA, Johnson R, Nuti S, Luisi K, Ulmer JB, Steff AM, Jalah R, Bertholet S, Stokes AH, Yu D. Maruggi G, et al. Among authors: spickler c. Mol Ther. 2022 May 4;30(5):1897-1912. doi: 10.1016/j.ymthe.2022.01.001. Epub 2022 Jan 3. Mol Ther. 2022. PMID: 34990810 Free PMC article. Clinical Trial.
Repeated-Dose Toxicity, Biodistribution, and Shedding Assessments With a ChAd155 Respiratory Syncytial Virus Vaccine Candidate Evaluated in Rabbits and Rats.
Stokes AH, Planty C, Pion J, Ancian P, Rogue A, Bansard C, Silvano J, Papineau D, Ben Abdeljelil N, Maruggi G, Song H, Spickler C, Blouin K, Dubois G, Rodriguez LA, Baumeister J, Steff AM, Destexhe E. Stokes AH, et al. Among authors: spickler c. Int J Toxicol. 2022 Aug;41(4):263-275. doi: 10.1177/10915818221101788. Epub 2022 Jun 2. Int J Toxicol. 2022. PMID: 35653115
Phosphatidylinositol 4-kinase III beta is essential for replication of human rhinovirus and its inhibition causes a lethal phenotype in vivo.
Spickler C, Lippens J, Laberge MK, Desmeules S, Bellavance É, Garneau M, Guo T, Hucke O, Leyssen P, Neyts J, Vaillancourt FH, Décor A, O'Meara J, Franti M, Gauthier A. Spickler C, et al. Antimicrob Agents Chemother. 2013 Jul;57(7):3358-68. doi: 10.1128/AAC.00303-13. Epub 2013 May 6. Antimicrob Agents Chemother. 2013. PMID: 23650168 Free PMC article.
In vitro resistance profile of the hepatitis C virus NS3 protease inhibitor BI 201335.
Lagacé L, White PW, Bousquet C, Dansereau N, Dô F, Llinas-Brunet M, Marquis M, Massariol MJ, Maurice R, Spickler C, Thibeault D, Triki I, Zhao S, Kukolj G. Lagacé L, et al. Among authors: spickler c. Antimicrob Agents Chemother. 2012 Jan;56(1):569-72. doi: 10.1128/AAC.05166-11. Epub 2011 Oct 24. Antimicrob Agents Chemother. 2012. PMID: 22024816 Free PMC article.
Design, synthesis and biological evaluation of novel aminothiazoles as antiviral compounds acting against human rhinovirus.
Décor A, Grand-Maître C, Hucke O, O'Meara J, Kuhn C, Constantineau-Forget L, Brochu C, Malenfant E, Bertrand-Laperle M, Bordeleau J, Ghiro E, Pesant M, Fazal G, Gorys V, Little M, Boucher C, Bordeleau S, Turcotte P, Guo T, Garneau M, Spickler C, Gauthier A. Décor A, et al. Among authors: spickler c. Bioorg Med Chem Lett. 2013 Jul 1;23(13):3841-7. doi: 10.1016/j.bmcl.2013.04.077. Epub 2013 May 7. Bioorg Med Chem Lett. 2013. PMID: 23726345
Direct visualization of protein interactions in plant cells.
Subramaniam R, Desveaux D, Spickler C, Michnick SW, Brisson N. Subramaniam R, et al. Among authors: spickler c. Nat Biotechnol. 2001 Aug;19(8):769-72. doi: 10.1038/90831. Nat Biotechnol. 2001. PMID: 11479572
12 results