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The MAP kinase JNK2 mediates cigarette smoke-induced arterial thrombosis.
Breitenstein A, Stämpfli SF, Reiner MF, Shi Y, Keller S, Akhmedov A, Schaub Clerigué A, Spescha RD, Beer HJ, Lüscher TF, Tanner FC, Camici GG. Breitenstein A, et al. Among authors: spescha rd. Thromb Haemost. 2017 Jan 5;117(1):83-89. doi: 10.1160/TH16-05-0351. Epub 2016 Oct 20. Thromb Haemost. 2017. PMID: 27761579
Aging induces endothelial dysfunction while sparing arterial thrombosis.
Stämpfli SF, Akhmedov A, Gebhard C, Lohmann C, Holy EW, Rozenberg I, Spescha R, Shi Y, Lüscher TF, Tanner FC, Camici GG. Stämpfli SF, et al. Arterioscler Thromb Vasc Biol. 2010 Oct;30(10):1960-7. doi: 10.1161/ATVBAHA.110.206920. Epub 2010 Aug 5. Arterioscler Thromb Vasc Biol. 2010. PMID: 20689076 Free article.
Post-ischaemic silencing of p66Shc reduces ischaemia/reperfusion brain injury and its expression correlates to clinical outcome in stroke.
Spescha RD, Klohs J, Semerano A, Giacalone G, Derungs RS, Reiner MF, Rodriguez Gutierrez D, Mendez-Carmona N, Glanzmann M, Savarese G, Kränkel N, Akhmedov A, Keller S, Mocharla P, Kaufmann MR, Wenger RH, Vogel J, Kulic L, Nitsch RM, Beer JH, Peruzzotti-Jametti L, Sessa M, Lüscher TF, Camici GG. Spescha RD, et al. Eur Heart J. 2015 Jul 1;36(25):1590-600. doi: 10.1093/eurheartj/ehv140. Epub 2015 Apr 22. Eur Heart J. 2015. PMID: 25904764 Free article.
Reduced nitric oxide bioavailability mediates cerebroarterial dysfunction independent of cerebral amyloid angiopathy in a mouse model of Alzheimer's disease.
Merlini M, Shi Y, Keller S, Savarese G, Akhmedov A, Derungs R, Spescha RD, Kulic L, Nitsch RM, Lüscher TF, Camici GG. Merlini M, et al. Among authors: spescha rd. Am J Physiol Heart Circ Physiol. 2017 Feb 1;312(2):H232-H238. doi: 10.1152/ajpheart.00607.2016. Epub 2016 Nov 11. Am J Physiol Heart Circ Physiol. 2017. PMID: 27836896 Free article.
Endothelial LOX-1 activation differentially regulates arterial thrombus formation depending on oxLDL levels: role of the Oct-1/SIRT1 and ERK1/2 pathways.
Akhmedov A, Camici GG, Reiner MF, Bonetti NR, Costantino S, Holy EW, Spescha RD, Stivala S, Schaub Clerigué A, Speer T, Breitenstein A, Manz J, Lohmann C, Paneni F, Beer JH, Lüscher TF. Akhmedov A, et al. Among authors: spescha rd. Cardiovasc Res. 2017 Apr 1;113(5):498-507. doi: 10.1093/cvr/cvx015. Cardiovasc Res. 2017. PMID: 28199510
Expression of the aging gene p66Shc is increased in peripheral blood monocytes of patients with acute coronary syndrome but not with stable coronary artery disease.
Franzeck FC, Hof D, Spescha RD, Hasun M, Akhmedov A, Steffel J, Shi Y, Cosentino F, Tanner FC, von Eckardstein A, Maier W, Lüscher TF, Wyss CA, Camici GG. Franzeck FC, et al. Among authors: spescha rd. Atherosclerosis. 2012 Jan;220(1):282-6. doi: 10.1016/j.atherosclerosis.2011.10.035. Epub 2011 Nov 2. Atherosclerosis. 2012. PMID: 22100252 Free article.
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